Home Categories Pharmaceutical intermediates 5,7-Dichloropyrazolo[1,5-a]pyrimidine
BD3632845

5,7-Dichloropyrazolo[1,5-a]pyrimidine , 97% , 57489-77-7

CAS NO.:57489-77-7

Empirical Formula: C6H3Cl2N3

Molecular Weight: 188.01

MDL number: MFCD08273918

Pack Size Price Stock Quantity
100mg RMB48.00 In Stock
250mg RMB68.00 In Stock
1g RMB117.60 In Stock
5g RMB452.80 In Stock
10g RMB800.80 In Stock
25g RMB1455.20 In Stock
100g RMB4579.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 68-71 °C(Solv: ethanol (64-17-5))
Density  1.69±0.1 g/cm3(Predicted)
storage temp.  under inert gas (nitrogen or Argon) at 2–8 °C
pka -1.68±0.30(Predicted)
InChI InChI=1S/C6H3Cl2N3/c7-4-3-5(8)11-6(10-4)1-2-9-11/h1-3H
InChIKey JMTFWCYVZOFHLR-UHFFFAOYSA-N
SMILES C12=CC=NN1C(Cl)=CC(Cl)=N2

Description and Uses

5,7-Dichloropyrazolo[1,5-a]pyrimidine is a pharmaceutical intermediate compound that can be used in a palladium-catalysed pharmaceutical synthesis cross-coupling reaction. 2,4-Dichloroquinoline reacts with benzylzinc and phenylzinc reagents in the presence of catalytic quantities of palladium complexes to yield only α-substituted products.2,4-Dichloroquinolines have been found to react with benzylzinc and phenylzinc reagents in catalytic amounts of palladium compounds to produce only α-substituted products. LiCl was found to be an effective additive for γ-selective coupling reactions. These α- or γ-selective coupling conditions are applicable to the reaction of 5,7-Dichloropyrazolo[1,5-a]pyrimidine and biphenylmethyl zinc reagents in the synthesis of angiotensin II receptor antagonists. This regioselectivity should be generally applicable to other α,γ-dichloropyrazine systems[1].

Safety

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H332-H335
Precautionary statements  P261-P280-P305+P351+P338
HS Code  2933599590

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