1-((3AR,4R,6R,6aR)-6-(hydroxymethyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)pyrimidine-2,4(1H,3H)-dione , 98% , 362-43-6

CAS NO.：362-43-6

Empirical Formula: C12H16N2O6

Molecular Weight: 284.27

MDL number: MFCD00034509

EINECS: 206-647-7

PRODUCT Properties

• Melting point: 163-166 °C
• Boiling point: 426.76°C (rough estimate)
• Density: 1.2932 (rough estimate)
• refractive index: 1.5460 (estimate)
• storage temp.: -20°C
• solubility: Chloroform (Slightly, Heated), DMSO (Slightly), Methanol (Slightly)
• pka: 9.25±0.10(Predicted)
• form: Fine Crystalline Powder or Needles
• color: White
• BRN: 32671
• InChI: InChI=1S/C12H16N2O6/c1-12(2)19-8-6(5-15)18-10(9(8)20-12)14-4-3-7(16)13-11(14)17/h3-4,6,8-10,15H,5H2,1-2H3,(H,13,16,17)/t6-,8-,9-,10-/m1/s1
• InChIKey: GFDUSNQQMOENLR-PEBGCTIMSA-N
• SMILES: OC[C@H]1O[C@@H](N2C=CC(=O)NC2=O)[C@@H]2OC(O[C@H]12)(C)C
• CAS DataBase Reference: 362-43-6(CAS DataBase Reference)

Description and Uses

2',3'-Isopropylideneuridine has been shown to inhibit binding of pestivirus inhibitors by monoclonal antibodies. 2',3'-Isopropylideneuridine was also found to inhibit the replication of human immunodeficiency virus (HIV) in tissue culture by binding to the viral RNA polymerase and inhibiting its activity, preventing viral replication.

2′,3′-O-Isopropylideneuridine is used in the chemical synthesis of N-benzoylated uridine derivatives and N³-substituted 2′,3′-O-isopropylideneuridines with central nervous system (CNS) depressant activity.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H317
• Precautionary statements: P261-P272-P280-P302+P352-P333+P313-P321-P363-P501
• Safety Statements: 24/25
• WGK Germany: 3
• HS Code: 29339900