3-Phenyl-1,2,4-thiadiazol-5-amine , 95% , 17467-15-1

CAS NO.：17467-15-1

Empirical Formula: C8H7N3S

Molecular Weight: 177.23

MDL number: MFCD00003159

EINECS: 241-485-0

PRODUCT Properties

• Melting point: 152-156 °C
• Density: 1.2353 (rough estimate)
• refractive index: 1.5700 (estimate)
• storage temp.: 2-8°C
• form: powder
• color: White
• InChI: InChI=1S/C8H7N3S/c9-8-10-7(11-12-8)6-4-2-1-3-5-6/h1-5H,(H2,9,10,11)
• InChIKey: OYAHSBDYBOBAAQ-UHFFFAOYSA-N
• SMILES: S1C(N)=NC(C2=CC=CC=C2)=N1
• CAS DataBase Reference: 17467-15-1(CAS DataBase Reference)
• EPA Substance Registry System: 1,2,4-Thiadiazol-5-amine, 3-phenyl- (17467-15-1)

Description and Uses

5-Amino-3-phenyl-1,2,4-thiadiazole is an important organic synthetic reagent with remarkable reactivity and stability and has been used in the synthesis of a variety of heterocyclic compounds including 1,2,4-triazol-3-ylphenyls, derivatives of 2-aryl-5-amino-thiadiazole, 5-amino-1,2,4-thiadiazol-3-phenyls, and 5 -amino-1,2,4-thiadiazole-3-phenyl-3-methyl derivatives. It is also used in the synthesis of polymers such as poly(5-amino-3-phenyl-1,2,4-thiadiazole). In addition, 5-amino-3-phenyl-1,2,4-thiadiazole is an inhibitor of cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX). The compound inhibits the release of pro-inflammatory cytokines such as tumour necrosis factor-α (TNF-α) and interleukin-1β (IL-1β).

3-Phenyl-1,2,4-thiadiazol-5-amine is used as a reactant in the preparation of thiazole and thiadiazole derivatives as potent and selective human adenosine A3 receptor antagonists.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H319-H335
• Precautionary statements: P261-P301+P312-P302+P352-P304+P340-P305+P351+P338
• Hazard Codes: Xn,Xi
• Risk Statements: 36/37/38-20/21/22-41-22
• Safety Statements: 36/37/39-26-22
• HazardClass: IRRITANT
• HS Code: 29341000