NFATINhibitor , 98% , 249537-73-3

Synonym(s):
VIVIT

CAS NO.：249537-73-3

Empirical Formula: C75H118N20O22S

Molecular Weight: 1683.93

MDL number: MFCD02683959

PRODUCT Properties

• Boiling point: 1982.4±65.0 °C(Predicted)
• Density: 1.334±0.06 g/cm3(Predicted)
• storage temp.: -20°C
• solubility: DMSO: 15 mg/ml; Water: 10 mg/ml
• form: solid
• pka: 3.12±0.10(Predicted)
• color: White to off-white
• Water Solubility: Soluble to 2 mg/ml in water
• Sequence: H-Met-Ala-Gly-Pro-His-Pro-Val-Ile-Val-Ile-Thr-Gly-Pro-His-Glu-Glu-OH

Description and Uses

NFAT inhibitor is a cell-permeable compound that selectively inhibits calcineurin-mediated dephosphorylation of NFAT. At 100 μM, this inhibitor effectively blocks calcineurin binding to NFAT without disrupting other calcineurin-dependent pathways, unlike the immunosuppressants cyclosporin A and FK506 which indiscriminately block all calcineurin phosphatase activity. NFAT inhibitor can disrupt NFAT-dependent expression of IL-2 and TNF-α when transfected in Jurak T cells and can prevent the activation and proliferation of T cells both in vitro (~ 43% at 1 μM using mixed lymphocyte cultures) and in vivo (10 mg/kg using C3H/HeN mice).

NFAT Inhibitor, VIVIT has been used to study the signaling pathways involved in controlling inhibitory molecules and subsequent onset of T-cell impairment.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H319-H335
• Precautionary statements: P261-P280-P301+P312-P302+P352-P305+P351+P338
• Safety Statements: 22-24/25
• WGK Germany: 3
• HS Code: 2933299090