1-(4-Aminophenyl)-3-morpholino-5,6-dihydropyridin-2(1H)-one , 95% , 1267610-26-3

CAS NO.：1267610-26-3

Empirical Formula: C15H19N3O2

Molecular Weight: 273.33

MDL number: MFCD22581648

PRODUCT Properties

• Melting point: >246°C (dec.)
• Boiling point: 491.5±45.0 °C(Predicted)
• Density: 1.277±0.06 g/cm3(Predicted)
• storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• solubility: Chloroform (Slightly), Methanol (Slightly)
• form: Solid
• pka: 4.96±0.10(Predicted)
• color: Off-White to Pale Beige
• InChI: InChI=1S/C15H19N3O2/c16-12-3-5-13(6-4-12)18-7-1-2-14(15(18)19)17-8-10-20-11-9-17/h2-6H,1,7-11,16H2
• InChIKey: YUGIGSPFTMLIMA-UHFFFAOYSA-N
• SMILES: C1(=O)N(C2=CC=C(N)C=C2)CCC=C1N1CCOCC1

Description and Uses

1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone is an intermediate in the synthesis of Apixaban (A726700), A potent, direct, selective, and orally active inhibitor of coagulation factor Xa. It is a potential new oral coagulant that may be useful prevention of venous thromboembolism in total hip, knee replacement orthopedic surgery and stroke in treatment of patient with venous thromboembolic disorder or with atrial fibrillation.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H319-H335
• Precautionary statements: P261-P305+P351+P338