SNS-032 , 99+% , 345627-80-7
CAS NO.:345627-80-7
Empirical Formula: C17H24N4O2S2
Molecular Weight: 380.53
MDL number: MFCD09833875
Pack Size | Price | Stock | Quantity |
25mg | RMB515.20 | In Stock |
|
50mg | RMB772.80 | In Stock |
|
100mg | RMB1158.40 | In Stock |
|
250mg | RMB1737.60 | In Stock |
|
1g | RMB4342.40 | In Stock |
|
others | Enquire |
PRODUCT Properties
Melting point: | 171-173 °C |
Density | 1.28±0.1 g/cm3(Predicted) |
storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
solubility | DMSO (Slightly), Methanol (Slightly) |
form | Solid |
pka | 7.33±0.70(Predicted) |
color | White to Off-White |
Description and Uses
Cyclin-dependent kinases (CDKs) are key regulators of cell cycle progression and are therefore promising targets for cancer therapy. SNS-032 is an ATP-competitive inhibitor of Cdk9, 2, and 7 with IC50 values of 4, 38, and 62 nM, respectively. It is selective for these kinases and displays no additional activity against a panel of 190 kinases (IC50s = >1,000 nM). SNS-032 can block the cell cycle, inhibit transcription, and induce apoptosis in multiple myeloma RPMI-8226 cells with an IC90 value of 0.3 μM. This compound has been shown to induce apoptosis by inhibiting the transcription of the anti-apoptotic proteins, Mcl-1 and XIAP.
SNS 032 is a selective inhibitor of Cyclin-dependent Kinase (CDK) 2,7, and 9.
Safety
Symbol(GHS) | GHS07 |
Signal word | Warning |
Hazard statements | H302-H315-H319-H335 |
Precautionary statements | P261-P305+P351+P338 |
HS Code | 29349990 |