Home Categories Biochemical Engineering SNS-032
BD3176445

SNS-032 , 99+% , 345627-80-7

CAS NO.:345627-80-7

Empirical Formula: C17H24N4O2S2

Molecular Weight: 380.53

MDL number: MFCD09833875

Pack Size Price Stock Quantity
25mg RMB515.20 In Stock
50mg RMB772.80 In Stock
100mg RMB1158.40 In Stock
250mg RMB1737.60 In Stock
1g RMB4342.40 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 171-173 °C
Density  1.28±0.1 g/cm3(Predicted)
storage temp.  under inert gas (nitrogen or Argon) at 2–8 °C
solubility  DMSO (Slightly), Methanol (Slightly)
form  Solid
pka 7.33±0.70(Predicted)
color  White to Off-White

Description and Uses

Cyclin-dependent kinases (CDKs) are key regulators of cell cycle progression and are therefore promising targets for cancer therapy. SNS-032 is an ATP-competitive inhibitor of Cdk9, 2, and 7 with IC50 values of 4, 38, and 62 nM, respectively. It is selective for these kinases and displays no additional activity against a panel of 190 kinases (IC50s = >1,000 nM). SNS-032 can block the cell cycle, inhibit transcription, and induce apoptosis in multiple myeloma RPMI-8226 cells with an IC90 value of 0.3 μM. This compound has been shown to induce apoptosis by inhibiting the transcription of the anti-apoptotic proteins, Mcl-1 and XIAP.

SNS 032 is a selective inhibitor of Cyclin-dependent Kinase (CDK) 2,7, and 9.

Safety

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
HS Code  29349990

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