Tris(3-hydroxypropyltriazolylmethyl)amine , 97% , 760952-88-3

Synonym(s):
3,3′,3′′-(4,4′,4′′-(Nitrilotris(methylene))tris(1H-1,2,3-triazole-4,1-diyl))tris(propan-1-ol);THPTA

CAS NO.：760952-88-3

Empirical Formula: C18H30N10O3

Molecular Weight: 434.51

MDL number: MFCD27665386

PRODUCT Properties

• Melting point: 331-336°C (decomposition)
• Boiling point: 723.8±70.0 °C(Predicted)
• Density: 1.44±0.1 g/cm3(Predicted)
• storage temp.: 2-8°C
• solubility: DMSO (Slightly), Methanol (Very Slightly)
• pka: 14.34±0.10(Predicted)
• form: Solid
• color: White to Off-White

Description and Uses

THPTA is a water-soluble, very effective ligand for Cu(I)-catalyzed Alkyne-Azide click chemistry reactions (CuAAC). It serves a dual purpose: 1) Acceleration of the CuAAC reaction by maintaining the Cu(I) oxidation state of copper sources and 2) Protection of biomolecules from oxidative damage during the labeling reaction. THPTA is a superior alternative to water-insoluble TBTA. a) J. Am. Chem. Soc. 2011, 133, 17993. b) Bioconjugate Chem. 2010, 21, 1912.

Tris(3-hydroxypropyltriazolylmethyl)amine when complexed to copper(I) can be used as a catalyst.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319-H335
• Precautionary statements: P261-P264-P271-P280-P302+P352-P305+P351+P338
• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 26
• WGK Germany: 3
• HS Code: 2933.99.9701