Tris[(1-benzyl-1<i>H</i>-1,2,3-triazol-4-yl)methyl]amine , ≥95.0% , 510758-28-8

CAS NO.：510758-28-8

Empirical Formula: C30H30N10

Molecular Weight: 530.63

MDL number: MFCD09265124

EINECS: 693-028-3

PRODUCT Properties

• Melting point: 132-143℃
• Boiling point: 762.4±70.0 °C(Predicted)
• Density: 1.27±0.1 g/cm3(Predicted)
• storage temp.: -20°C
• solubility: Soluble in DMSO, DMF.
• form: Solid
• pka: 2.44±0.50(Predicted)
• color: White
• Stability: store cold
• InChIKey: WKGZJBVXZWCZQC-UHFFFAOYSA-N
• SMILES: N1(CC2=CC=CC=C2)C=C(CN(CC2=CN(CC3=CC=CC=C3)N=N2)CC2=CN(CC3=CC=CC=C3)N=N2)N=N1

Description and Uses

TBTA was introduced shortly after the copper-catalyzed azide-alkyne cycloaddition reaction was discovered to mitigate thermodynamic instability of Cu(I) in aerobic media. TBTA is a water-insoluble ligand and must be first dissolved in DMSO or DMF. J Am Chem Soc., 143 (18), 6787-6791. T. R. Chan, R. Hilgraf, K. B. Sharpless, V. V. Fokin, Org. Lett. 2004, 6, 2853.

Tris-(benzyltriazolylmethyl)amine is a useful reagent for copper (I) catalyzed azide-alkyne cycloadditions.?It can also be used for postsynthetic labelling of alkyne-modified DNA.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H413
• Precautionary statements: P501-P273
• WGK Germany: 3
• HS Code: 2933998090