tert-Butyl1-hydroxy-3,6,9,12-tetraoxapentadecan-15-oate , 97% , 518044-32-1
Synonym(s):
tert-Butyl 1-hydroxy-3,6,9,12,15-pentaoxaoctadecan-18-oate;HO-PEG5-CO-OtBu
Pack Size | Price | Stock | Quantity |
100mg | RMB29.60 | In Stock |
|
250mg | RMB44.00 | In Stock |
|
1g | RMB101.60 | In Stock |
|
5g | RMB437.60 | In Stock |
|
25g | RMB2049.60 | In Stock |
|
others | Enquire |
PRODUCT Properties
Boiling point: | 406.8±35.0 °C(Predicted) |
Density | 1.04746 g/mL |
refractive index | n/D 1.4492 |
storage temp. | 2-8°C |
solubility | Soluble in Water, DCM |
form | liquid |
pka | 14.36±0.10(Predicted) |
color | Colorless to Light yellow to Light orange |
Description and Uses
Hydroxy-PEG4-t-butyl ester is a PEG linker containing a hydroxyl group with a t-butyl ester. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The t-butyl protected carboxyl group can be deprotected under acidic conditions.
This heterobifunctional, PEGylated crosslinker features a hydroxyl group at one end and t-butyl-protected carboxylic acid at the other, which can be deprotected with acidic conditions. The hydrophillic PEG linker facilitates solubility in biological applications. Hydroxy-PEG4-t-butyl ester can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC? molecules) for targeted protein degradation.
Safety
Symbol(GHS) | GHS07 |
Signal word | Warning |
Hazard statements | H302-H315-H319-H335 |
Precautionary statements | P261-P305+P351+P338 |
HS Code | 2918999090 |