tert-Butyl1-hydroxy-3,6,9,12-tetraoxapentadecan-15-oate , 97% , 518044-32-1

Synonym(s):
tert-Butyl 1-hydroxy-3,6,9,12,15-pentaoxaoctadecan-18-oate;HO-PEG5-CO-OtBu

CAS NO.：518044-32-1

Empirical Formula: C15H30O7

Molecular Weight: 322.39

MDL number: MFCD11041117

PRODUCT Properties

• Boiling point: 406.8±35.0 °C(Predicted)
• Density: 1.04746 g/mL
• refractive index: n/D 1.4492
• storage temp.: 2-8°C
• solubility: Soluble in Water, DCM
• form: liquid
• pka: 14.36±0.10(Predicted)
• color: Colorless to Light yellow to Light orange

Description and Uses

Hydroxy-PEG4-t-butyl ester is a PEG linker containing a hydroxyl group with a t-butyl ester. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The t-butyl protected carboxyl group can be deprotected under acidic conditions.

This heterobifunctional, PEGylated crosslinker features a hydroxyl group at one end and t-butyl-protected carboxylic acid at the other, which can be deprotected with acidic conditions. The hydrophillic PEG linker facilitates solubility in biological applications. Hydroxy-PEG4-t-butyl ester can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^? molecules) for targeted protein degradation.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H319-H335
• Precautionary statements: P261-P305+P351+P338
• HS Code: 2918999090