BD2827245
Pf-9366 , 98% , 72882-78-1
Synonym(s):
7-Chloro-N,N-dimethyl-5-phenyl-[1,2,4]triazolo[4,3-a]quinoline-1-ethanamine;PF 9366;PF9366
| Pack Size | Price | Stock | Quantity |
| 50mg | RMB663.20 | In Stock |
|
| 100mg | RMB1126.40 | In Stock |
|
| 250mg | RMB1913.60 | In Stock |
|
| 1g | RMB5166.40 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | 182-183.5 °C(Solv: ethyl acetate (141-78-6); hexane (110-54-3)) |
| Density | 1.25±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | Soluble in DMSO (up to 20 mg/ml). |
| pka | 8.75±0.28(Predicted) |
| form | solid |
| color | Beige |
| Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
Description and Uses
PF-9366 (72882-78-1) is an allosteric inhibitor (IC50?= 420 nM) of methionine adenosyltransferase 2A (Mat2A), the primary enzyme responsible for extrahepatic synthesis of S-adenosyl-L-methionine (SAM).1?It inhibited cellular SAM production in H520 lung and Huh-7 liver cancer cells with IC50’s of 1.2 μM and 225 nM respectively.
PF-9366 is a novel inhibitor of human methionine adenosyltransferase 2A (Mat2A), the extrahepatic isoform.
