PF-573228 , ≥98% , 869288-64-2
Synonym(s):
6-[4-(3-Methanesulfonyl-benzylamino)-5-trifluoromethyl-pyrimidin-2-ylamino]-3,4-dihydro-1H-quinolin-2-one;Focal Adhesion Kinase Inhibitor II - CAS 869288-64-2 - Calbiochem;PF-228;PF-573,228, PF-228, 6-((4-((3-(Methanesulfonyl)benzyl)amino)-5-trifluoromethylpyrimidin-2-yl)amino)-3,4-dihydro-1H-quinolin-2-one, FAK Inhibitor II, Cdk7 Inhibitor V
CAS NO.：869288-64-2
Empirical Formula: C22H20F3N5O3S
Molecular Weight: 491.49
MDL number: MFCD11519967
| Pack Size | Price | Stock | Quantity |
| 10MG | RMB639.20 | In Stock |
|
| 50MG | RMB1839.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | >242°C (dec.) |
| Density | 1.459 |
| storage temp. | 2-8°C |
| solubility | DMSO: ≥20mg/mL |
| form | powder |
| pka | 14.30±0.20(Predicted) |
| color | white to off-white |
| InChIKey | HESLKTSGTIBHJU-UHFFFAOYSA-N |
Description and Uses
Focal adhesion kinases (FAKs) are non-receptor tyrosine kinases that play roles in regulating diverse processes, including cell adhesion, spreading, migration, proliferation, and apoptosis. They are overexpressed in many types of cancer. PF-573228 inhibits FAK with IC50 values of 4 and 30-100 nM for a purified recombinant catalytic fragment of FAK and in cultured cells, respectively. It is 50-250-fold selective for FAK over other protein kinases. PF-573228 can inhibit chemotactic and haptotactic migration of cells as well as prevent focal adhesion turnover.
A novel focal adhesion kinase inhibitor that has been shown to suppress the adverse phenotype of endocrine-resistant breast cancer cells and improve endocrine response in endocrine-sensitive cells.
