Ceftriaxone , 98+% , 73384-59-5

CAS NO.：73384-59-5

Empirical Formula: C18H18N8O7S3

Molecular Weight: 554.58

MDL number: MFCD00865013

EINECS: 277-405-6

PRODUCT Properties

• Melting point: 155 °C
• Density: 1.96±0.1 g/cm3(Predicted)
• storage temp.: 2-8°C(protect from light)
• solubility: DMSO (Slightly), Methanol (Slightly)
• pka: pKa –3.2±0.6 (Uncertain);–1.8±0.2 (Uncertain);2.57±0.50 (Uncertain);2.90±0.50 (Uncertain);8.03±0.40 (Uncertain)
• form: Solid
• color: Off-White to Pale Yellow
• Stability: Hygroscopic

Description and Uses

Ceftriaxone has the same C-7 side-chain moiety as cefotaxime and ceftizoxime, but the C-3 side chain consists of a metabolically stable and activating thiotriazinedione in place of the normal acetyl group. The C-3 side chain is sufficiently acidic that at normal pH, it forms an enolic sodium salt; thus, the commercial product is a disodium salt.

This drug has a broad spectrum of antimicrobial action that includes the majority of the clinically significant microorganisms: Gram-positive, Gram-negative, aerobic, anaerobic, and blue-pus bacillus. It is resistant with respect to most beta-lactamases of Gram-positive and Gram-negative bacteria.
It is used for peritonitis, sepsis, meningitis, cholangitis, empyema of the gall bladder, pneumonia, lung abscesses, pyelonephritis, infections of the bones, joints, skin, soft tissues, abdominal and gynecological infections, and for infected wounds and burns. The main synonym of this drug is rocefin.

Safety

• Symbol(GHS): GHS07,GHS08
• Signal word: Danger
• Hazard statements: H315-H317-H334-H319-H335
• Precautionary statements: P261-P285-P304+P341-P342+P311-P501-P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362-P261-P272-P280-P302+P352-P333+P313-P321-P363-P501
• Hazard Codes: Xn
• Risk Statements: 42/43
• Safety Statements: 22-24-37-45
• HS Code: 29349990