NM107 , 98% , 20724-73-6

Synonym(s):
2′-C-Methyl Cytidine;NM107

CAS NO.：20724-73-6

Empirical Formula: C10H15N3O5

Molecular Weight: 257.24

MDL number: MFCD02682947

EINECS: 200-001-2

PRODUCT Properties

• Melting point: 243-245°C
• Boiling point: 523.9±60.0 °C(Predicted)
• Density: 1.72±0.1 g/cm3(Predicted)
• storage temp.: -20°C
• solubility: H2O: >20mg/mL
• form: powder
• pka: 13.53±0.70(Predicted)
• color: white to off-white
• InChIKey: PPUDLEUZKVJXSZ-VPCXQMTMSA-N

Description and Uses

2''-C-Methylcytidine (2CMC) is a ribonucleoside with broad-spectrum antiviral activity. It reduces the number of viral plaques in BHK-21 cells infected with dengue type 2, reovirus type 1, West Nile, and yellow fever RNA viruses with EC₅₀ values of 95, 26, 80, and 75 μM, respectively. 2CMC inhibits hepatitis C virus (HCV) replication (EC₅₀ = 2.2 μM in a replicon assay) and protects MDBK cells from infection with bovine virus diarrhea virus (BVDV; EC₅₀ = 2.2 μM) and human coronavirus (HCoV; EC₅₀ = 90 μM). It also reduces infectious virus yield in BHK-21 cells infected with foot-and-mouth disease virus (FMDV; EC₅₀ = 6.4 μM) and swine vesicular disease virus (SVDV; EC₅₀ = 45.2 μM). In vivo, 2CMC reduces viral shedding to undetectable levels in a mouse model of persistent norovirus infection.

2’-C-Methyl Cytidine (cas# 20724-73-6) is a compound useful in organic synthesis.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319-H335
• Precautionary statements: P261-P264-P271-P280-P302+P352-P305+P351+P338
• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 26
• WGK Germany: 3