tert-Butyl 4-(6-((6-bromo-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate , 97% , 571188-82-4

CAS NO.：571188-82-4

Empirical Formula: C27H34BrN7O3

Molecular Weight: 584.51

MDL number: MFCD09834002

EINECS: 1592732-453-0

PRODUCT Properties

• Melting point: >250℃
• Boiling point: 720.0±70.0 °C(Predicted)
• Density: 1.439±0.06 g/cm3(Predicted)
• storage temp.: 2-8°C(protect from light)
• pka: 5.24±0.10(Predicted)
• InChIKey: UTSOLZWQDXJQRH-UHFFFAOYSA-N
• SMILES: N1(C(OC(C)(C)C)=O)CCN(C2=CC=C(NC3=NC=C4C(C)=C(Br)C(=O)N(C5CCCC5)C4=N3)N=C2)CC1

Description and Uses

6-Desacetyl-6-bromo-N-Boc Palbociclib is an impurity of Palbociclib (P139900),(also known as compound number PD-0332991) is an experimental drug for the treatment of breast cancer being developed by Pfizer. It is a selective inhibitor of the cyclin-dependent kinases CDK4 and CDK6.Also, it is derived from 6-Bromo-2-chloro-8-cyclopentyl-5-methylpyrido-[2,3-d]pyrimidin-7(8H)-one (B682195), which is used to prepare pyridino[2,3-d]pyrimidin-7(8H)-one derivatives as CDK4 and/or CDK6 inhibitors useful in the treatment of diseases.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H319-H335
• Precautionary statements: P261-P305+P351+P338