BD0338432
tert-Butyl 6-cyano-2-(2-(4-ethyl-3-iodophenyl)propan-2-yl)-1H-indole-3-carboxylate , 98% , 1256584-75-4
| Pack Size | Price | Stock | Quantity |
| 250mg | RMB36.80 | In Stock |
|
| 1g | RMB91.20 | In Stock |
|
| 5g | RMB319.20 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Boiling point: | 609.3±55.0 °C(Predicted) |
| Density | 1.43±0.1 g/cm3(Predicted) |
| pka | 14.00±0.30(Predicted) |
| InChI | InChI=1S/C25H27IN2O2/c1-7-16-9-10-17(13-19(16)26)25(5,6)22-21(23(29)30-24(2,3)4)18-11-8-15(14-27)12-20(18)28-22/h8-13,28H,7H2,1-6H3 |
| InChIKey | QJJFMODIDDQXRV-UHFFFAOYSA-N |
| SMILES | N1C2=C(C=CC(C#N)=C2)C(C(OC(C)(C)C)=O)=C1C(C1=CC=C(CC)C(I)=C1)(C)C |
Description and Uses
tert-?Butyl 6-?Cyano-?2-?(2-?(4-?ethyl-?3-?iodophenyl)?propan-?2-?yl)?-?1H-?indole-?3-?carboxylate is an intermediate of Alectinib (C183360), a highly selective and potent anaplastic lymphoma kinase (ALK) inhibitor capable of blocking the resistant gatekeeper mutant, which results in reduced cell growth.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501 |
