Zafirlukast , ≥99% , 107753-78-6
Synonym(s):
N-[3-[[2-Methoxy-4-[[[(2-methylphenyl)sulfonyl]amino]carbonyl]phenyl]methyl]-1-methyl-1H-indol-5-yl]carbamic acid cyclopentyl ester
CAS NO.：107753-78-6
Empirical Formula: C31H33N3O6S
Molecular Weight: 575.68
MDL number: MFCD00864775
| Pack Size | Price | Stock | Quantity |
| 50MG | RMB159.20 | In Stock |
|
| 100mg | RMB231.20 | In Stock |
|
| 250MG | RMB519.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 139°C |
| Density | 1.32±0.1 g/cm3(Predicted) |
| storage temp. | room temp |
| solubility | DMSO: ≥28mg/mL |
| pka | 4.94±0.10(Predicted) |
| form | solid |
| color | White or pink |
| Merck | 14,10108 |
| Stability: | Stable for 2 years as supplied. Protect from exposure to moisture. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| CAS DataBase Reference | 107753-78-6(CAS DataBase Reference) |
| EPA Substance Registry System | Carbamic acid, N-[3-[[2-methoxy-4-[[[(2-methylphenyl)sulfonyl]amino]carbonyl]phenyl]methyl]-1-methyl-1H-indol-5-yl]-, cyclopentyl ester (107753-78-6) |
Description and Uses
Accolate was launched in Ireland, Finland and the US for treatment of asthma. Prepared via an eight step synthesis from methyl 3-methoxy-4- methylbenzoate, zafirlukast acts as a LTD4 antagonist and is the first compound of a new class of drugs. LTC4, LTD4 and LTE4 were determined to be the constituents of the slow-reacting substance of anaphylaxis (SRS-A) which was found to induce asthma effects (bronchoconstriction, increased vascular permeability resulting in edema, cellular infiltration of airway tissues and decreased mucociliary transport). Thus an inhibitor of their synthesis would at least attenuate these symptoms. Zafirlukast binds to the CysLT receptor LT-1 and blocks the effect of LTC4, LTD4 and LTE4. The drug is an oral twice daily formulation that reversed an LTD4 challenge, attenuated the response of platelet-activating factor (PAF), an allergen and cold air challenge and exercise-induced asthma.
antiasthmatic;leukotriene receptor antagonist (LTRA)
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| WGK Germany | 3 |
| RTECS | FB3966200 |
| HS Code | 2935.90.6000 |
