2′,3′-Dideoxycytidine , 99% , 7481-89-2

Synonym(s):
2′,3′-Dideoxycytidine;ddC

CAS NO.：7481-89-2

Empirical Formula: C9H13N3O3

Molecular Weight: 211.22

MDL number: MFCD00012188

EINECS: 620-762-3

PRODUCT Properties

• Melting point: 217-218 °C(lit.)
• Boiling point: 350.9°C (rough estimate)
• alpha: D25 +81° (c = 0.635 in water)
• Density: 1.2605 (rough estimate)
• refractive index: 78 ° (C=0.5, H2O)
• storage temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• solubility: DMSO (Slightly, Heated), Methanol (Slightly), Water (Slightly, Sonicated)
• form: powder
• pka: 14.44±0.10(Predicted)
• color: colorless
• Water Solubility: 5-10 g/100 mL at 19 ºC
• Merck: 14,10109
• BRN: 654956
• Stability: Stable. Combustible. Incompatible with strong oxidizing agents.
• InChIKey: WREGKURFCTUGRC-POYBYMJQSA-N
• CAS DataBase Reference: 7481-89-2(CAS DataBase Reference)
• IARC: 2B (Vol. 76) 2000
• EPA Substance Registry System: Cytidine, 2',3'-dideoxy- (7481-89-2)

Description and Uses

Zalcitabine is an orally active dideoxynucleoside andog for combination use with zidovudine in advanced HIV infection and also as monotherapy for AIDS patients who cannot tolerate or have not responded to zidovudine. It has a similar mechanism of action (inhibition of reverse transcriptase) to didanosine. Like didanosine, its side effect profile includes peripheral neuropathy. Unlike zidovudine, zalcitabine does not cause bone marrow suppression.

A pyrimidine nucleoside analogue with antiviral activity.

Safety

• Symbol(GHS): GHS08
• Signal word: Warning
• Hazard statements: H351
• Precautionary statements: P281
• Hazard Codes: Xn,C
• Risk Statements: 40-36/37-34
• Safety Statements: 22-36-45-36/37/39-27-26
• WGK Germany: 3
• RTECS: HA3870000
• F: 10-23
• HS Code: 2934990002
• Hazardous Substances Data: 7481-89-2(Hazardous Substances Data)