A8448212
YM155 (Sepantronium Bromide) , ≥98% , 781661-94-7
CAS NO.：781661-94-7
Empirical Formula: C20H19BrN4O3
Molecular Weight: 443.294
MDL number: MFCD11983133
| Pack Size | Price | Stock | Quantity |
| 5MG | RMB328.80 | In Stock |
|
| 25MG | RMB1199.20 | In Stock |
|
| 100MG | RMB3421.60 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | >180°C (dec.) |
| storage temp. | -20° |
| solubility | Soluble in DMSO (up to 25 mg/ml). |
| form | solid |
| color | Tan to yellow |
| Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
Description and Uses
YM-155 (781661-94-7) is a novel small molecule survivin suppressant. YM-155 suppresses expression of survivin (a member of the IAP family) and induced apoptosis in human tumor cell lines at 10 nmol/L with little effect on other IAP or Bcl-2 family members.1?Overcomes erlotinib resistance in EGFR mutation-positive non-small cell lung cancer.2?Induces DNA damage.3?YM-155 induces an autophagy-dependent cell death in adenoid cystic carcinoma cells.4
YM155 is a potent IAP (inhibitor of apoptosis proteins) inhibitor for survivin with IC50 of 0.54 nM.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| HS Code | 29339900 |
