Wnt-C59 (C59) , ≥98% , 1243243-89-1
Synonym(s):
Porcn Inhibitor II, C59 - CAS 1243243-89-1 - Calbiochem;Wnt-C59, Wnt Pathway Inhibitor XVI, 2-(4-(2-Methylpyridin-4-yl)phenyl)-N-(4-(pyridin-3-yl)phenyl)acetamide
| Pack Size | Price | Stock | Quantity |
| 5MG | RMB559.20 | In Stock |
|
| 25MG | RMB1919.20 | In Stock |
|
| 100MG | RMB5279.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | >159°C (dec.) |
| Boiling point: | 628.3±55.0 °C(Predicted) |
| Density | 1.198±0.06 g/cm3(Predicted) |
| storage temp. | +2C to +8C |
| solubility | Soluble in DMSO (up to 7 mg/ml) or in Ethanol (up to 6 mg/mL) |
| form | Off-white powder |
| pka | 13.78±0.70(Predicted) |
| color | Tan |
| Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month. |
Description and Uses
Wnt-C59 (1243243-89-1) is a potent (IC50 = 74 pmol/L) inhibitor of Porcupine (PORCN), a Wnt-acyltransferase.1 Blockage of Wnt-acyltransferase prevents secretion of all Wnt isoforms.? It was able to block progression of mammary tumors in MMTV-WNT1 transgenic mice.1? Wnt-C59 strongly inhibited the growth of intestinal neoplasia in RZ-mutant mice.2? Wnt-C59 was able to efficiently differentiate pluripotent stem cells into cortical neurons (CTIP2+/COUP-TF1).3? Wnt-C59 was also able to dramatically attenuate kidney fibrosis via inhibition of collagen mRNA expression and expression of inflammatory cytokines.4
Wnt-C59 is a porcupine homolog – Drosophila (PORCN) inhibitor for Wnt3A-mediated activation of a multimerized TCF-binding site driving luciferase.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| HS Code | 2933399990 |
