Venlafaxine hydrochloride , ≥98%(HPLC) , 99300-78-4

Synonym(s):
(+/-)-1-[2-(Dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexanol hydrochloride;Effexor;Venlafaxine hydrochloride

CAS NO.：99300-78-4

Empirical Formula: C17H28ClNO2

Molecular Weight: 313.86

MDL number: MFCD03658865

EINECS: 619-421-1

PRODUCT Properties

• Melting point: 207-209°C
• Flash point: 9℃
• storage temp.: 2-8°C
• solubility: H2O: >10mg/mL
• form: powder
• color: white
• Merck: 14,9946
• BCS Class: 1
• InChIKey: QYRYFNHXARDNFZ-UHFFFAOYSA-N
• CAS DataBase Reference: 99300-78-4(CAS DataBase Reference)
• EPA Substance Registry System: Cyclohexanol, 1-[2-(dimethylamino)-1-(4-methoxyphenyl)ethyl]-, hydrochloride (1:1 (99300-78-4)

Description and Uses

Venlafaxine hydrochloride, a novel phenethylamine derivative, was introduced in the U.S.A. as an antidepressant. Venlafaxine is reported to be the first in the class of the second-generation of antidepressants with dual serotonidnorepinephrine reuptake inhibitory activity. Venlafaxine lacks any affinity for muscarinic, cholinergic, histaminergic and noradrenergic receptors and therefore, has an unusually favorable side effect profile compared with classical tricyclic antidepressants and shows less cardiotoxicity. In addition, venlafaxine has a rapid onset of action that makes it unique among the antidepressant agents. Other indications for venlafaxine include the treatment of obsessive and panic disorders, and obesity. Both enantiomers of venlafaxine were reported to have similar biological activity.

A selective serotonin noradrenaline reuptake inhibitor. Used as an antidepressant

Safety

• Symbol(GHS): GHS09
• Signal word: Danger
• Hazard statements: H411
• Precautionary statements: P273-P391-P501
• Hazard Codes: Xi,T,F
• Risk Statements: 36/37/38-36-39/23/24/25-23/24/25-11
• Safety Statements: 26-37/39-45-36/37-16-7
• RIDADR: UN1230 - class 3 - PG 2 - Methanol, solution
• WGK Germany: 3
• RTECS: GV8872760
• HS Code: 29225090