A8362012
Volasertib (BI 6727) , ≥97% , 755038-65-4
CAS NO.：755038-65-4
Empirical Formula: C34H50N8O3
Molecular Weight: 618.81
MDL number: MFCD20926414
EINECS: 813-258-1
| Pack Size | Price | Stock | Quantity |
| 5MG | RMB559.20 | In Stock |
|
| 25MG | RMB1919.20 | In Stock |
|
| 250MG | RMB5464.00 | In Stock |
|
| 100MG | RMB5599.20 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | 86 - 87*C |
| Density | 1.26 |
| storage temp. | -20° |
| solubility | Soluble in DMSO (up to at least 25 mg/ml). |
| pka | 14.26±0.40(Predicted) |
| form | solid |
| color | Off-white |
| Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month. |
Description and Uses
Volasertib (755038-65-4) is an extremely potent and selective inhibitor (IC50’s: Plk1= 0.87 nM, Plk2 = 5 nM, Plk3 = 56 nM) of Polo-like kinase 1, a critical controller of multiple essential steps of mitosis.1?It has shown efficacy in multiple solid xenograft tumors models1?and in clinical studies in patients with acute myeloid leukemia2. Volasertib has also been shown to potently inhibit BRD43?(Kd = 79 nM3, IC50’s bromodomains 1 and 2 of BRD4 = 300 and 770 nM respectively2).
Volasertib (BI 6727) is a highly potent Polo-like kinase (PLK) inhibitor.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H315-H319 |
| Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 |
