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A8360912

Vortioxetine , ≥98% , 508233-74-7

CAS NO.:508233-74-7

Empirical Formula: C18H22N2S

Molecular Weight: 298.45

MDL number: MFCD22380814

EINECS: 823-919-6

Pack Size Price Stock Quantity
10MG RMB63.20 In Stock
50MG RMB112.00 In Stock
250MG RMB289.60 In Stock
1g RMB1001.60 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 115-117°C
Boiling point: 424.8±45.0 °C(Predicted)
Density  1.16
storage temp.  -20°C Freezer
solubility  DMSO (Slightly), Methanol (Slightly)
pka 8.85±0.10(Predicted)
form  Solid
color  White to Off-White
InChI InChI=1S/C18H22N2S/c1-14-7-8-17(15(2)13-14)21-18-6-4-3-5-16(18)20-11-9-19-10-12-20/h3-8,13,19H,9-12H2,1-2H3
InChIKey YQNWZWMKLDQSAC-UHFFFAOYSA-N
SMILES N1(C2=CC=CC=C2SC2=CC=C(C)C=C2C)CCNCC1

Description and Uses

In September 2013, vortioxetine (also known as Lu AA21004) was approved in the United States for the treatment of major depressive disorder (MDD). Vortioxetine was discovered from a designed multiple ligand approach to identifying an antidepressant agent that combined SERT inhibition with 5-HT1A agonism to more rapidly desensitize 5-HT1A receptors and 5-HT3A antagonism to improve mood and cognitive function. Vortioxetine has a human SERT IC50=5.4 nM, an EC50=200 nM as a human 5-HT1A receptor agonist (efficacy=96%; Ki=39 nM), and an IC50=12 nM as a human 5-HT3A receptor antagonist (Ki=3.7 nM). It has weak inhibition of the dopamine and norepinephrine transporters, but high affinity for the human β1-noradrenergic receptor (Ki=46 nM), human 5-HT1B receptor (Ki=33 nM, partial agonist), and the human 5-HT-7 receptor (Ki=19 nM, antagonist).

Vortioxetine can be used in biological study of effectiveness of long term vortioxetine treatment of patients with major depressive disorder.

Safety

Symbol(GHS) 
GHS08
Signal word  Warning
Hazard statements  H371-H373-H361
Precautionary statements  P260-P314-P501-P201-P202-P281-P308+P313-P405-P501-P260-P264-P270-P309+P311-P405-P501
Hazardous Substances Data 508233-74-7(Hazardous Substances Data)

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