Vitamin B₁₂ , Used for cell culture and insect cell culture , 68-19-9

Synonym(s):
Cyanocobalamin;Vitamin B12;CC;Cyanocobalmin;Cyanocob(III)alamin

CAS NO.：68-19-9

Empirical Formula: C63H88CoN14O14P

Molecular Weight: 1355.37

MDL number: MFCD00151092

EINECS: 200-680-0

PRODUCT Properties

• Melting point: >300°C
• Boiling point: >300 °C
• alpha: 23656 -59 ± 9° (dil aq soln)
• Flash point: 9℃
• storage temp.: 2-8°C
• solubility: Sparingly soluble in water and in ethanol (96 per cent), practically insoluble in acetone. The anhydrous substance is very hygroscopic.
• form: Crystalline Powder or Crystals
• pka: pKa 3.28±0.04(H2O,D2O t=23±0.5 Iunspeci?ed) (Uncertain)
• color: Red to dark red
• Odor: dark red cryst. or powd., odorless and tasteless
• Water Solubility: Soluble
• Sensitive: Hygroscopic
• Merck: 14,10014
• BRN: 4122889
• Exposure limits: NIOSH: IDLH 25 mg/m3
• Stability: Hygroscopic. Keep cold and dry.
• InChIKey: RMRCNWBMXRMIRW-WZHZPDAFSA-L
• LogP: 3.570 (est)
• EPA Substance Registry System: Vitamin B12 (68-19-9)

Description and Uses

Prototype of the family of naturally occurring cobalt coordination compounds knows as corrinoids. Analogs of vitamin B12 which differ only in the β-ligand of the cobalt are termed cobalamins. Synthesi zed almost exclusively by bacteria. Dietary sources include fish, meat, liver, and dairy products; plants have little or no cobalamins. Converted by the body into its bioactive forms, methylcobalamin and cobamamide, which serve as enzyme cofactors. Severe deficiency may result in megaloblastic anemia and/or neurological impairment.

Safety

• Symbol(GHS): GHS02,GHS06,GHS08
• Signal word: Danger
• Hazard statements: H225-H301+H311+H331-H370
• Precautionary statements: P210-P260-P280-P301+P310-P311
• HS Code: 2936260000
• Hazardous Substances Data: 68-19-9(Hazardous Substances Data)
• Toxicity: LD50 intravenous in mouse: 2gm/kg