Ursolic acid , Analysis standard product, 98.5% , 77-52-1

Synonym(s):
3β-Hydroxy-12-ursen-28-ic acid;3β-Hydroxy-urs-12-en-28-oic acid, CG7, PTP1B Inhibitor VII, PTP Inhibitor XXVII, PTPN2/TCPTP Inhibitor II, SHP2 Inhibitor IV;3β-Hydroxy-urs-12-en-28-oic acid, CG7, PTPN2/TCPTP Inhibitor II, SHP2 Inhibitor IV, PTP1B Inhibitor VII, PTP Inhibitor XXVII;Ursolic Acid - CAS 77-52-1 - Calbiochem

CAS NO.：77-52-1

Empirical Formula: C30H48O3

Molecular Weight: 456.71

MDL number: MFCD00009621

EINECS: 201-034-0

PRODUCT Properties

• Melting point: 292 °C (dec.) (lit.)
• alpha: 59 º (c=0.3, pyridine)
• Boiling point: 502.79°C (rough estimate)
• Density: 1.0261 (rough estimate)
• refractive index: 1.4940 (estimate)
• storage temp.: 2-8°C
• solubility: Soluble in DMSO (up to 25 mg/ml with warming)
• pka: 4.68±0.70(Predicted)
• form: Crystalline Powder or Needles
• color: White to off-white
• optical activity: +6620 (c 1.4, C5H5N)
• Water Solubility: insoluble
• Merck: 14,9890
• BRN: 2228563
• Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
• LogP: 8.731 (est)

Description and Uses

Ursolic Acid is a Triterpene acid used in cosmetics, that also has STAT3 pathway inhibiting properties. It inhibits endothelial cell proliferation and migration (IC50=5 μM) and angiogenesis. Promotes skeletal muscle rejuvenation via enhanced SIRT1 expression. Induces apoptosis in malignant mesothelioma cells. Ursolic acid protects against muscle atrophy and boosts muscle growth (see also tomatidine T538500).

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302
• Precautionary statements: P280-P305+P351+P338
• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 24/25-36-26
• WGK Germany: -
• RTECS: YU9520000
• F: 10-23
• HS Code: 29181990