3,3',5-Triiodo-L-thyronine , >98.0%(HPLC) , 6893-02-3

Synonym(s):
Liothyronine;Reverse T₃;rT(3);T₃;O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine

CAS NO.：6893-02-3

Empirical Formula: C15H12I3NO4

Molecular Weight: 650.97

MDL number: MFCD00002593

EINECS: 229-999-3

PRODUCT Properties

• Melting point: 234-238 °C(lit.)
• alpha: 23 º (c=2 in ethanol)
• Boiling point: 232°C (rough estimate)
• Density: 2.2155 (estimate)
• Flash point: 9°C
• storage temp.: -20°C
• solubility: DMSO (Slightly), Methanol (Very Slightly)
• form: powder
• pka: pKa 8.5 (Uncertain);8.4 (Uncertain);8.45 (Uncertain)
• color: Off-white to pale yellow
• optical activity: [α]25/D +23.0°, c = 2 in 1 N HCl: ethanol, 1:2
• Water Solubility: Insoluble in water, ethanol and propylene glycol. Soluble in dilute alkalies.
• Sensitive: Light Sensitive
• Merck: 14,5510
• BRN: 2710227
• Stability: Light Sensitive
• CAS DataBase Reference: 6893-02-3(CAS DataBase Reference)

Description and Uses

Crystalline T3 (liothyronine sodium, Cytomel) has a rapid onset and short duration of action. It is the therapy of choice when it is desirable to have rapid onset or cessation of activity, such as in patients with heart disease.

3,3’,5-Triiodo-L-thyronine (Levothyroxine EP Impurity A) is one of the hormones produced by the thyroid gland that is involved in the maintenance of metabolic homeostasis. Also produced in peripheral tissues as the active metabolite of Thyroxine.

Safety

• Symbol(GHS): GHS07
• Signal word: Danger
• Hazard statements: H315-H319-H335
• Precautionary statements: P261-P280a-P304+P340-P305+P351+P338-P405-P501a
• Hazard Codes: Xn,Xi,T,F
• Risk Statements: 20/21/22-36/37/38-39/23/24/25-23/24/25-11
• Safety Statements: 36-26-36/37/39-45-36/37-16
• RIDADR: UN1230 - class 3 - PG 2 - Methanol, solution
• WGK Germany: 3
• RTECS: AY6750000
• F: 8
• HS Code: 29225090
• Hazardous Substances Data: 6893-02-3(Hazardous Substances Data)
• Toxicity: LDLo oral in rat: 7500mg/kg