Home Categories API Teprenone [mixture of (5E,9E,13E)- and (5Z,9E,13E)- isomers]
A7845612

Teprenone [mixture of (5E,9E,13E)- and (5Z,9E,13E)- isomers] , ≥95.0% , 6809-52-5

Synonym(s):
6,10,14,18-Tetramethyl-5,9,13,17-nonadecatetraen-2-one, mixture of (5E,9E,13E) and (5Z,9E,13E) isomers;GGA;Selbex;Teprenone;UNII-S8S8451A4O

CAS NO.:6809-52-5

Empirical Formula: C23H38O

Molecular Weight: 330.55

MDL number: MFCD00866901

EINECS: 614-276-0

Pack Size Price Stock Quantity
200MG RMB135.20 In Stock
1G RMB440.80 In Stock
5G RMB1768.00 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Boiling point: bp0.01 155-160°
Density  d420.5 0.9081
refractive index  nD20 1.4947
storage temp.  -20°C
solubility  DMSO: >5mg/mL
form  liquid
color  clear
Merck  14,9228
Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
InChIKey SBOCYPUKNYDTSX-DMLVRTFPSA-N
LogP 8.200 (est)
CAS DataBase Reference 6809-52-5(CAS DataBase Reference)

Description and Uses

Teprenone (geranylgeranylacetone) is an antiulcer agent whose synthesis was inspired by the gastric protecting properties of Coenzyme Q10. Teprenone is reported to act via enhancement of gastric mucosal glycoprotein secretion.

An anti-ulcerative. Geranylgeranylacetone can induce expression of HSP70, HSPB8, and HSPB1. Induction of HSP70 expression is protective against the development of various diseases, such as inflammatory bowel disease, hypoxic/ischemic brain injury and spinal and bulbar muscular atrophy (cytoprotective and anti-inflammatory effects). Reports indicate that GGA protects against NSAID-induced gastric and intestinal lesions by induction of HSP70 expression. Other studies have shown that GGA induces expression of HSPB8 and HSPB1 and reduces the formation of amyloid oligomers as well as insoluble aggregates in HSPB5 R120G TG mice.

Safety

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P305+P351+P338
WGK Germany  3
RTECS  RA5391300
HS Code  2914.19.0000

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