2',3',5'-Tri-O-acetyluridine , ≥99% , 4105-38-8

Synonym(s):
TAU;MAPT;MAPTL;Microtubule-associated protein tau;MTBT1

CAS NO.：4105-38-8

Empirical Formula: C15H18N2O9

Molecular Weight: 370.31

MDL number: MFCD00023795

EINECS: 223-881-5

PRODUCT Properties

• Melting point: 127.0 to 131.0 °C
• Density: 1.43±0.1 g/cm3(Predicted)
• storage temp.: Inert atmosphere,Store in freezer, under -20°C
• solubility: Chloroform (Slightly), Dichloromethane (Slightly), DMSO (Slightly)
• form: Solid
• pka: 9.39±0.10(Predicted)
• color: Off-White
• InChI: InChI=1S/C15H18N2O9/c1-7(18)23-6-10-12(24-8(2)19)13(25-9(3)20)14(26-10)17-5-4-11(21)16-15(17)22/h4-5,10,12-14H,6H2,1-3H3,(H,16,21,22)/t10-,12-,13-,14-/m1/s1
• InChIKey: AUFUWRKPQLGTGF-QRMSVCKNSA-N
• SMILES: C(OC(=O)C)[C@H]1O[C@@H](N2C=CC(=O)NC2=O)[C@H](OC(=O)C)[C@@H]1OC(=O)C
• CAS DataBase Reference: 4105-38-8(CAS DataBase Reference)

Description and Uses

Uridine triacetate is an orally available pro-drug of uridine approved by the FDA for the treatment of the rare autosomal recessive disorder called hereditary orotic aciduria. The drug was also approved for treating overdose of two chemotherapies (fluorouracil and capecitabine). Uridine triacetate was developed by Wellstat Therapeutics and licensed to BTG.

2’,3’,5’-Triacetyluridine is used in the treatment of Alzheimer’s disease in mice and provide neuroprotective effects. Shown to also decrease depressive symptoms and increases in brain pH bipolar patients.

Safety

• Safety Statements: 24/25
• WGK Germany: 3
• HS Code: 29349990