Home Categories Biochemical Engineering 4-Thiouridine
A7792912

4-Thiouridine , 98% , 13957-31-8

Synonym(s):
RNA synthesis inhibitor

CAS NO.:13957-31-8

Empirical Formula: C9H12N2O5S

Molecular Weight: 260.27

MDL number: MFCD00006538

EINECS: 237-735-3

Pack Size Price Stock Quantity
5MG RMB207.20 In Stock
25MG RMB439.20 In Stock
100MG RMB849.60 In Stock
500mg RMB2399.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 139-140℃ (ethanol )
Density  1.72±0.1 g/cm3(Predicted)
storage temp.  -20°C
solubility  DMSO (Slightly), Methanol (Slightly, Sonicated)
form  crystalline
pka 4.75±0.20(Predicted)
color  light yellow
PH 8.2
Water Solubility  Soluble in water (20 mg/ml), and methanol (10 mg/ml).
λmax 245,331 (pH 6.5);316 (pH 12)
InChIKey ZLOIGESWDJYCTF-XVFCMESISA-N
CAS DataBase Reference 13957-31-8(CAS DataBase Reference)

Description and Uses

4-Thiouridine (4-SU) is a photoactivatable ribonucleoside analog that is widely used for RNA analysis, including short-range RNA-RNA crosslinking and nascent RNA labeling. The crosslinking thio moiety is attached directly to the nucleotide base, thus 4-SU differs from uridine only by a single sulfur substitution. This offers the advantage of incorporating into an RNA chain with minimal structural perturbation and with similar base-pairing properties, reducing the likelihood that substitution will impair RNA interactions or activities.

Nucleotide analogue, essential for cell growth in certain bacterial species. This compound is also able to chelate with certain metal ions, and in tRNA it can act as a built-in antiphotomutagenic agent that protects Escherichia coli cells against mutagenesis.

Safety

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P280-P301+P312-P302+P352-P305+P351+P338
Safety Statements  24/25
WGK Germany  3
HS Code  29349990

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