Thiazole , 99% , 288-47-1

CAS NO.：288-47-1

Empirical Formula: C3H3NS

Molecular Weight: 85.13

MDL number: MFCD00005315

EINECS: 206-021-3

PRODUCT Properties

• Melting point: -33°C
• Boiling point: 117-118 °C (lit.)
• Density: 1.2 g/mL at 25 °C (lit.)
• FEMA: 3615 | THIAZOLE
• refractive index: n20/D 1.538(lit.)
• Flash point: 72 °F
• storage temp.: Keep in dark place,Inert atmosphere,2-8°C
• pka: 2.44(at 20℃)
• form: Liquid
• color: Clear colorless to yellow
• Specific Gravity: 1.200
• Odor: at 0.10 % in propylene glycol. pyridine nutty meaty
• Odor Type: fishy
• Water Solubility: slightly soluble
• Sensitive: Air & Light Sensitive
• Merck: 14,9307
• JECFA Number: 1032
• BRN: 103852
• Stability: Stable. Incompatible with strong oxidizing agents.
• LogP: 0.44
• CAS DataBase Reference: 288-47-1(CAS DataBase Reference)
• NIST Chemistry Reference: Thiazole(288-47-1)
• EPA Substance Registry System: Thiazole (288-47-1)

Description and Uses

Thiazole is used as a flavoring agent and in the preparation of dyes and rubber accelerators. It serves as a component of the vitamin thiamine (B1). It acts as a protected formyl group used in natural product synthesis. It reacts with alkyl lithium and Grignard?s reagent to prepare organometallic complexes. It is involved in the electrophilic aromatic substitution and nucleophilic aromatic substitution at C-5 and C-2 positions respectively. Further, it undergoes alkylation reaction to get thiazolium cation, which is used as a catalyst in the Stetter reaction and the Benzoin condensation. In addition to this, it is involved in the preparation of alagebrium.

Safety

• Symbol(GHS): GHS02,GHS07
• Signal word: Danger
• Hazard statements: H225-H302
• Precautionary statements: P210-P233-P240-P241-P242-P301+P312
• Hazard Codes: Xn,F
• Risk Statements: 10-22-37/38-41
• Safety Statements: 16-26-39
• RIDADR: UN 1993 3/PG 3
• WGK Germany: 3
• RTECS: XJ1290000
• F: 8-10-23
• TSCA: T
• HazardClass: 3
• PackingGroup: II
• HS Code: 29341000