Home Categories Biochemical Engineering L-HomoarginineHydrochloride
A7780658

L-HomoarginineHydrochloride , 10mMinWater , 1483-01-8

Synonym(s):
(S)-2-Amino-6-guanidinohexanoic acid hydrochloride

CAS NO.:1483-01-8

Empirical Formula: C7H17ClN4O2

Molecular Weight: 224.69

MDL number: MFCD00012622

EINECS: 216-045-6

Pack Size Price Stock Quantity
1ml RMB159.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 213-215 °C(lit.)
alpha  18 º (c=1, 1N HCl)
storage temp.  Inert atmosphere,Room Temperature
solubility  H2O: 50 mg/mL, clear to slightly hazy, faintly yellow
form  Granular Powder
color  White
Water Solubility  Soluble in water(50 mg/mL).
BRN  4016621
Stability: Moisture Sensitive
CAS DataBase Reference 1483-01-8(CAS DataBase Reference)

Description and Uses

L-Homoarginine is an uncompetitive and organ-specific inhibitor of alkaline phosphatases. This non-essential amino acid inhibits human bone and liver alkaline phosphatases but has no effect on placental or intestinal isoenzymes. In vitro, L-homoarginine inhibits [3H]thymidine uptake by mouse myeloma MOPC 104E cells and inhibits proliferation of C3H/He mouse osteosarcoma cells. Pre-treatment with L-homoarginine delays in vivo tumor growth in a murine C3H/He osteosarcoma model. It also inhibits high-protein diet-induced pancreatic growth and enzyme secretion in bile-pancreatic juice-diverted rats, a model for the induction of pancreatic enzyme secretion with hypercholecystokininemia.

An inhibitor of alkaline phosphatase isoenzymes. It is also an inhibitor of cellular transport of arginine by a sodium-independent high affinity y+ transporter. The substitution of homoarginine for arginine or lysine renders proteins resistant to proteolysis by trypsin. Arginine residues are often located at the active centers of proteins and enzymes. Replacing these arginines with homoarginine can elucidate protein function and structural requirements.

Safety

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  24/25-36/37/39-27-26
WGK Germany  3
HS Code  29252900

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