Toremifene Citrate , 98% , 89778-27-8

Synonym(s):
(Z)-2-(4-(4-Chloro-1,2-diphenyl-1-butenyl)phenoxy)-N,N-dimethylethanamine;Acapodene;Fareston;GTx 006;Z-Toremifene

CAS NO.：89778-27-8

Empirical Formula: C32H36ClNO8

Molecular Weight: 598.08

MDL number: MFCD01729016

EINECS: 663-344-6

PRODUCT Properties

• Melting point: 160-162°C
• Boiling point: 146-148C
• Density: 1,045g/cm
• refractive index: 1,416-1,418
• storage temp.: 2-8°C
• solubility: DMSO: >10mg/mL
• form: powder
• color: white to off-white
• Merck: 14,9550
• Stability: Light Sensitive

Description and Uses

Toremifene (citrate) is an orally bioavailable selective estrogen receptor modulator (SERM) that evokes tissue-dependent effects similar to that of tamoxifen . It has been shown to block estrogen-stimulated growth of MCF-7 breast cancer cells grown in tissue culture, to inhibit ovariectomy-induced bone loss in rats, and to stimulate endometrial growth similar to that of tamoxifen.

Toremifene citrate salt has been used:

• in cell-based ELISA
• as a positive control to detect its antiviral activity against Ebola virus (EBOV)
• to treat MCF7 and T47D breast cancer cell lines

Safety

• Symbol(GHS): GHS05,GHS07,GHS09
• Signal word: Danger
• Hazard statements: H302-H318-H410
• Precautionary statements: P273-P280-P301+P312+P330-P305+P351+P338+P310
• Hazard Codes: Xi,N,Xn
• Risk Statements: 36/37/38-50/53-41-22
• Safety Statements: 26-37/39-61-60-39
• RIDADR: UN 3077 9 / PGIII
• WGK Germany: 3
• RTECS: KH2156700