PRODUCT Properties
| Melting point: | 77 C |
| Boiling point: | 86-88C/2,5Torr |
| alpha | D20 +38° (alc) |
| Density | 1,191g/cm |
| refractive index | 1,536 |
| storage temp. | Sealed in dry,2-8°C |
| solubility | Soluble in Water (up to 25 mg/ml) |
| form | solid |
| pka | 9.47±0.20(Predicted) |
| color | White |
| optical activity | +37.926 (c 1.69, H2O) |
| Merck | 14,5759 |
| Stability: | Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 3 months. |
| LogP | 1.440 (est) |
| CAS DataBase Reference | 519-02-8(CAS DataBase Reference) |
| NIST Chemistry Reference | Matrine(519-02-8) |
Description and Uses
Matrine is an alkaloid isolated from the traditional Chinese medicine Sophora flavescens Aiton. The extraction process involves the use of organic solvents on dry roots, plants, and fruits of kushen 苦参 (Sophora flavescens Ait). Matrine is also present in S. alopecuroides L. and S. subprostrata Chun et T. Chen.
Chinese medicine Radix Sophora flavescentis have dampness eliminating insecticide and diuretic effects. Sophora flavescens is used for heat dysentery, hemafecia, jaundice and anuria, red leukorrhea, vulva pruritus, eczema, wet sores, skin itching, scabies, ringworm, and trichomonas vaginitis. Sophora flavescens is recorded in the ancient Materia Medica. “Southern Yunnan Materia Medica” also recorded the effects of Saphora flavescens.
Sophora flavescens is a species of Sophora japonica and is distributed in temperate and subtropical regions. Sophora flavescens is widely distributed in China, mainly in the north of Hebei, the west of Henan, and southwest of Shandong, Anhui, Hubei, and Guizhou.
(+)-Matrine is an alkaloid compound extracted from the roots of Sophora species which maintain anti-inflammatory, anti-cancer and a host of other positive pharmacological effects. Apoptotic agent.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P264-P270-P301+P312-P501 |
| Hazard Codes | Xn |
| Risk Statements | 20/21/22-37/38-41-48-22 |
| Safety Statements | 22-26-36/37/39-45-36/37 |
| WGK Germany | 3 |
| RTECS | OQ1754000 |
| HS Code | 13021990 |
