MonomethylFumarate , 10mMinDMSO , 2756-87-8
Synonym(s):
Fumaric acid monomethyl ester;Methyl hydrogen fumarate
CAS NO.：2756-87-8
Empirical Formula: C5H6O4
Molecular Weight: 130.1
MDL number: MFCD00063174
EINECS: 220-412-6
| Pack Size | Price | Stock | Quantity |
| 1ml | RMB159.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 144-145 °C (lit.) |
| Boiling point: | 250.0±23.0 °C(Predicted) |
| Density | 1.37 g/cm3 |
| storage temp. | 2-8°C |
| solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) |
| pka | 3.40±0.10(Predicted) |
| form | Solid |
| color | Off-White |
| λmax | 209nm(MeOH)(lit.) |
| CAS DataBase Reference | 2756-87-8(CAS DataBase Reference) |
Description and Uses
Monomethyl fumarate (MMF), a bioactive metabolite of fumaric acid ester, is an immunotherapy for psoriasis that causes decreased production of Th1 cytokines and lymphocytopenia. Monomethyl fumarate was shown to decrease DC response to LPS and decreased IL-12p70 and IL-10 production.
Monomethyl fumarate is used to treat the relapsing forms of multiple sclerosis (MS), including clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease. This medicine will not cure MS, but it may slow some of the disabling effects and decrease the number of relapses of the disease.
Fumaric Acid Monomethyl Ester is one of the most bioactive anti-psoriatic fumaric acid ester metabolite. Fumaric Acid Monomethyl Ester is potent nicotinic acid receptor agonist. Fumaric Acid Monomethy l Ester has also been shown to selectively stimulate of T helper 2 cytokine response.
