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A7740658

Fusidicacidsodiumsalt , 10mMinDMSO , 751-94-0

Synonym(s):
Fucidin;Fusidic acid sodium salt

CAS NO.:751-94-0

Empirical Formula: C31H49NaO6

Molecular Weight: 540.72

MDL number: MFCD00865135

EINECS: 212-030-3

Pack Size Price Stock Quantity
1ml RMB159.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: >200°C (dec.)
storage temp.  Keep in dark place,Inert atmosphere,2-8°C
solubility  H2O: soluble
form  Solid
color  White to Off-White
Water Solubility  Soluble in water
Sensitive  Moisture & Light Sensitive
Merck  13,4339

Description and Uses

Fusidic acid is a fusidane antibiotic originally isolated from F. coccineum. It is active against the Gram-positive bacteria S. aureus, S. pyogenes, C. diphtheriae, B. subtilis, and C. tetani (MIC50s = 0.01-20 μg/ml) but not the Gram-negative bacteria E. coli, S. typhimurium, and P. vulgaris or the fungi C. albicans and A. fumigatus (MIC50s = >100 μg/ml for all). Fusidic acid inhibits ribosomal recycling and protein translocation, processes mediated by elongation factor G (EF-G), in isolated E. coli ribosomes (IC50s = ~0.1 and ~200 μM, respectively). Topical administration of fusidic acid (2%) reduces the number of skin colony forming units (CFUs) and levels of TNF-α and IL-6 in a mouse model of methicillin-resistant S. aureus (MRSA) skin wound infection.

Antibacterial;Protein synthesis inhibitor GTPase coupled

Safety

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P301+P312+P330
Hazard Codes  Xn,Xi
Risk Statements  22-36/37/38
Safety Statements  26-36
WGK Germany  3
RTECS  LV5775000
HS Code  29419000
Toxicity LD50 in mice (g/kg): 0.2 i.v. (Godtfredsen, Nature 1962)

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