Fusidicacidsodiumsalt , 10mMinDMSO , 751-94-0
Synonym(s):
Fucidin;Fusidic acid sodium salt
CAS NO.：751-94-0
Empirical Formula: C31H49NaO6
Molecular Weight: 540.72
MDL number: MFCD00865135
EINECS: 212-030-3
| Pack Size | Price | Stock | Quantity |
| 1ml | RMB159.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | >200°C (dec.) |
| storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
| solubility | H2O: soluble |
| form | Solid |
| color | White to Off-White |
| Water Solubility | Soluble in water |
| Sensitive | Moisture & Light Sensitive |
| Merck | 13,4339 |
| CAS DataBase Reference | 751-94-0(CAS DataBase Reference) |
Description and Uses
Fusidic acid is a fusidane antibiotic originally isolated from F. coccineum. It is active against the Gram-positive bacteria S. aureus, S. pyogenes, C. diphtheriae, B. subtilis, and C. tetani (MIC50s = 0.01-20 μg/ml) but not the Gram-negative bacteria E. coli, S. typhimurium, and P. vulgaris or the fungi C. albicans and A. fumigatus (MIC50s = >100 μg/ml for all). Fusidic acid inhibits ribosomal recycling and protein translocation, processes mediated by elongation factor G (EF-G), in isolated E. coli ribosomes (IC50s = ~0.1 and ~200 μM, respectively). Topical administration of fusidic acid (2%) reduces the number of skin colony forming units (CFUs) and levels of TNF-α and IL-6 in a mouse model of methicillin-resistant S. aureus (MRSA) skin wound infection.
Antibacterial;Protein synthesis inhibitor GTPase coupled
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P301+P312+P330 |
| Hazard Codes | Xn,Xi |
| Risk Statements | 22-36/37/38 |
| Safety Statements | 26-36 |
| WGK Germany | 3 |
| RTECS | LV5775000 |
| HS Code | 29419000 |
| Toxicity | LD50 in mice (g/kg): 0.2 i.v. (Godtfredsen, Nature 1962) |
