Oxprenololhydrochloride , 10mMinDMSO , 6452-73-9
Synonym(s):
(RS)-1-(2-Allyloxyphenoxy)- 3-isopropylamino-2-propanol
CAS NO.：6452-73-9
Empirical Formula: C15H24ClNO3
Molecular Weight: 301.81
MDL number: MFCD00058008
EINECS: 229-260-5
| Pack Size | Price | Stock | Quantity |
| 1ml | RMB559.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 91-93°C |
| storage temp. | Store at +4°C |
| solubility | Very soluble in water, freely soluble in alcohol. |
| form | Solid |
| color | White to off-white |
Description and Uses
Oxprenolol is an orally bioavailable β-adrenergic receptor (β-AR) antagonist (Ki = 7.10 nM in a radioligand binding assay using rat heart tissue). It is non-selective and binds to both β1- and β2-ARs (Kds = 2.09 and 1.35 nM in isolated rat heart and uterus, respectively). Oxprenolol is selective for β-ARs over serotonin (5-HT) receptors in rat sarcolemmal membrane preparations (IC50s = 4.13 and 23,300 nM, respectively), but it binds to 5-HT1A receptors in rat hippocampus and 5-HT1B in rat striatum (Kis = 94.2 and 642 nM, respectively). Formulations containing oxprenolol have been used to treat hypertension and angina pectoris.
β-Adrenergic blocker. Antihypertensive, antianginal, antiarrhythmic.
Safety
| Symbol(GHS) |  GHS06 |
| Signal word | Danger |
| Hazard statements | H301 |
| Precautionary statements | P264-P270-P301+P310+P330-P405-P501 |
| Hazard Codes | Xi |
| RIDADR | UN 2811 6.1 / PGIII |
| RTECS | UA5277000 |
| HazardClass | IRRITANT |
| HS Code | 2922190900 |
| Toxicity | LD50 oral in rat: 214mg/kg |
