Gabapentin , 10mMinWater , 60142-96-3
Synonym(s):
1-(Aminomethyl)-cyclohexaneacetic acid;Gabapentin - CAS 60142-96-3 - Calbiochem;L-type Voltage Gated Ca2+ Channel Blocke, Gabapentin;Neurontin
CAS NO.：60142-96-3
Empirical Formula: C9H17NO2
Molecular Weight: 171.24
MDL number: MFCD00865286
EINECS: 262-076-3
| Pack Size | Price | Stock | Quantity |
| 1ml | RMB159.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 162°C |
| Boiling point: | 314.4±15.0 °C(Predicted) |
| Density | 1.058±0.06 g/cm3(Predicted) |
| Flash point: | 9℃ |
| storage temp. | 2-8°C |
| solubility | H2O: 10 mg/mL |
| form | solid |
| pka | pKa1 (25°) 3.68; pKa2 10.70 |
| color | off-white |
| Water Solubility | water: 100mM |
| Merck | 14,4319 |
| BRN | 2359739 |
| BCS Class | 3 |
| Stability: | Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 3 months. |
| InChIKey | UGJMXCAKCUNAIE-UHFFFAOYSA-N |
| CAS DataBase Reference | 60142-96-3(CAS DataBase Reference) |
| EPA Substance Registry System | Cyclohexaneacetic acid, 1-(aminomethyl)- (60142-96-3) |
Description and Uses
Gabapentin was introduced in 1993 in the UK and early 1994 in the USA as an adjunctive therapy in the treatment of refractory partial seizures and secondarily generalized tonic-clonic seizures. Although being a lipophilic analog of the neurotransmitter GABA, gabapentin appears to exert its anticonvulsive function by a GABA receptor independent mechanism, possibly involving the L-system amino acid transporter protein. Gabapentin easily crosses the blood brain barrier and exhibits a favorable pharmacokinetic profile with high tolerability. It does not interfere with the metabolism of other concomitant administered antiepileptic drugs, thus having a low potential for drug interactions. Studies are currently underway for the use of gabapentin as mono-therapy for the treatment of various seizures.
For the treatment of adult Restless Legs Syndrome (RLS) and postherpetic neuralgia (PHN).
Safety
| Symbol(GHS) |     GHS07,GHS08,GHS02,GHS06 |
| Signal word | Danger |
| Hazard statements | H225-H301+H311+H331-H370-H315-H319-H335-H360 |
| Precautionary statements | P210-P260-P280-P301+P310-P311-P302+P352+P312-P304+P340+P312-P370+P378-P403+P235-P201-P305+P351+P338-P308+P313-P261 |
| Hazard Codes | T,Xi,F |
| Risk Statements | 61-36/37/38-39/23/24/25-23/24/25-11 |
| Safety Statements | 53-26-36/37/39-45-36-36/37-16 |
| WGK Germany | 3 |
| RTECS | GU6496000 |
| HazardClass | IRRITANT |
| HS Code | 29224999 |
| Hazardous Substances Data | 60142-96-3(Hazardous Substances Data) |
