Gabapentin , 10mMinWater , 60142-96-3

Synonym(s):
1-(Aminomethyl)-cyclohexaneacetic acid;Gabapentin - CAS 60142-96-3 - Calbiochem;L-type Voltage Gated Ca2+ Channel Blocke, Gabapentin;Neurontin

CAS NO.：60142-96-3

Empirical Formula: C9H17NO2

Molecular Weight: 171.24

MDL number: MFCD00865286

EINECS: 262-076-3

PRODUCT Properties

• Melting point: 162°C
• Boiling point: 314.4±15.0 °C(Predicted)
• Density: 1.058±0.06 g/cm3(Predicted)
• Flash point: 9℃
• storage temp.: 2-8°C
• solubility: H₂O: 10 mg/mL
• form: solid
• pka: pKa1 (25°) 3.68; pKa2 10.70
• color: off-white
• Merck: 14,4319
• BRN: 2359739
• BCS Class: 3
• Stability: Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 3 months.
• InChIKey: UGJMXCAKCUNAIE-UHFFFAOYSA-N
• CAS DataBase Reference: 60142-96-3(CAS DataBase Reference)
• EPA Substance Registry System: Cyclohexaneacetic acid, 1-(aminomethyl)- (60142-96-3)

Description and Uses

γ-Aminobutyric acid (GABA) is a major inhibitory neurotransmitter that functions by binding to the GABA receptors located in the spinal cord. Gabapentin is a γ-aminobutyric acid (GABA) analogue that acts as an anticonvulsant with proven analgesic effects in various neuropathic pain syndromes such as Complex Regional Pain Syndrome type one (CRPS 1). It is also prescribed to multiple sclerosis patients to control dysesthesias and may be useful in reducing neuropathic pain caused by cancer and HIV infection. It does not bind to GABA receptors, does not influence neural uptake of GABA, and does not inhibit the GABA-metabolizing enzyme, GABA transaminase. Unlike GABA, which does not pass through the blood-brain barrier, gabapentin penetrates into the central nervous system and binds to the α₂δ-type voltage-gated calcium channels. The mechanism for the analgesic and anticonvulsant effects of gabapentin are not known.

For the treatment of adult Restless Legs Syndrome (RLS) and postherpetic neuralgia (PHN).

Safety

• Symbol(GHS): GHS07,GHS08,GHS02,GHS06
• Signal word: Danger
• Hazard statements: H225-H301+H311+H331-H370-H315-H319-H335-H360
• Precautionary statements: P210-P260-P280-P301+P310-P311-P302+P352+P312-P304+P340+P312-P370+P378-P403+P235-P201-P305+P351+P338-P308+P313-P261
• Hazard Codes: T,Xi,F
• Risk Statements: 61-36/37/38-39/23/24/25-23/24/25-11
• Safety Statements: 53-26-36/37/39-45-36-36/37-16
• WGK Germany: 3
• RTECS: GU6496000
• HazardClass: IRRITANT
• HS Code: 29224999
• Hazardous Substances Data: 60142-96-3(Hazardous Substances Data)