3,4',5-Trimethoxy-trans-stilbene , 97% , 22255-22-7

Synonym(s):
1,3-dimethoxy-5-[(1E)-2-(4-methoxyphenyl)ethenyl]-benzene; Tri-O-methylresveratrol; Trimethoxy-trans-stilbene

CAS NO.：22255-22-7

Empirical Formula: C17H18O3

Molecular Weight: 270.32

MDL number: MFCD02093500

EINECS: 694-659-7

PRODUCT Properties

• Melting point: 57°C
• Boiling point: 423.8±35.0 °C(Predicted)
• Density: 1.104±0.06 g/cm3(Predicted)
• storage temp.: Sealed in dry,2-8°C
• solubility: DMSO: ≥34mg/mL
• form: powder to crystal
• color: white to tan

Description and Uses

trans-trismethoxy Resveratrol is a polyketide synthase-derived stilbene originally isolated from Virola cuspidata that has diverse biological activities. It is cytotoxic to several cancer cell lines, including PC3, KB, HT-29, SW480, and HL-60 cells (IC₅₀s =3.6, 10.2, 16.1, 54, and 2.5 μM, respectively). trans-trismethoxy Resveratrol (15 μM) inhibits TNF-α-induced activation of NF-κB in HEK293T cells in a reporter assay. It inhibits angiogenesis in zebrafish embryos when used at a concentration of 0.1 μM.

Phenolic compounds, particularly flavonoids, from plant sources have long been observed to have antioxidant activity with potential benefits for human health. Resveratrol is a potent phenolic antioxidant found in grapes and red wine that also has antiproliferative and anti-inflammatory activity. When the three phenolic hydroxyl groups of resveratrol are converted to methyl ethers, the inhibition of cell growth and pro-apoptotic activities of resveratrol are enhanced.

Safety

• Symbol(GHS): GHS05,GHS07,GHS09
• Signal word: Danger
• Hazard statements: H315-H318-H335-H410
• Precautionary statements: P261-P264-P273-P280-P302+P352-P305+P351+P338
• Hazard Codes: Xi,N
• Risk Statements: 36/37/38-50/53-41-37/38
• Safety Statements: 26-36/37/39-61-60-39
• RIDADR: UN 3077 9 / PGIII
• HS Code: 2909.30.6000