PRODUCT Properties
Melting point: | 106-107 °C |
Boiling point: | 385.4±42.0 °C(Predicted) |
Density | 1.03±0.1 g/cm3(Predicted) |
storage temp. | -20°C |
solubility | DMSO: soluble10mg/mL (clear solution) |
form | powder |
color | white to beige |
InChIKey | HRYLQFBHBWLLLL-GRFSRWIASA-N |
LogP | 4.049 (est) |
Description and Uses
Costunolide is a germacranolide sesquiterpene lactone extracted from costus oil. With alantolactone and dehydrocostuslactone, it is a component of lactone mix used to elicit reactions in Compositae-sensitive patients. An erythema-multiform-like occupational contact dermatitis case occurred in a chemistry student after accidental exposure to costus oil (CJ Le Coz & JP Lepoittevin, unpublished results).
(+)-Costunolide is an inhibitor of osteoclast differentiation, acting as an anti-inflammatory and anti-oxidant agent. It is a sesquiterpene lactone which mediates apoptosis.