(S,S)-(+)-Tetrandrine , Analysis of standard products, ≥98%(HPLC), used for drug analysis , 518-34-3

Synonym(s):
(1β)-6,6′,7,12-Tetramethoxy-2,2′-dimethylberbaman

CAS NO.：518-34-3

Empirical Formula: C38H42N2O6

Molecular Weight: 622.75

MDL number: MFCD00082551

EINECS: 683-095-7

PRODUCT Properties

• Melting point: 219-222 °C(lit.)
• Boiling point: 662.81°C (rough estimate)
• alpha: 285 º (c=1, CHCl3)
• Density: 1.1528 (rough estimate)
• refractive index: 1.5300 (estimate)
• storage temp.: 2-8°C
• solubility: Chloroform (Slightly), Methanol (Slightly, Heated)
• form: solid
• pka: 7.70±0.20(Predicted)
• color: Off-White
• λmax: 283nm(EtOH)(lit.)
• Merck: 14,9231
• LogP: 3.550 (est)

Description and Uses

Recently it has been discovered that pronounced drug-dependence and related toxic effects occur in both dogs and rhesus monkeys with this alkaloid on intravenous injection with a dose of 10-150 mg/kg. When rapidly injected, the acute hypotensive effect is very marked and fatal at once. Following drug administration at toxic levels it is found that severe local tissue reaction heptaotoxicity and lymphoid necrosis occurs. At the highest dosage level there is a very definite nephrotoxicity in monkeys and some indications of this in dogs. The evidence available suggests that monkeys are less sensitive to hepatotoxicity with this drug than dogs.

Tetrandrine is a lipopolysaccharide-induced microglial suppressor, effectively reducing the production of bacterial inflammatory mediators. Anti-inflammatory, anti-nociceptive. Tetrandrine is used in China to treat high blood pressure. This drug blocked the TPC2 calcium channel required for the Ebola infection process (Robert A. Davey et al., Science 2015, DOI: 10.1126/science.1258758).

Safety

• Symbol(GHS): GHS06
• Signal word: Danger
• Hazard statements: H300
• Precautionary statements: P264-P270-P301+P310-P405-P501
• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 22-24/25-36-26
• WGK Germany: 3
• RTECS: XE9350000
• HS Code: 29349990