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A7694358

ML323 , 10mMinDMSO , 1572414-83-5

CAS NO.:1572414-83-5

Empirical Formula: C23H24N6

Molecular Weight: 384.48

MDL number: MFCD28099817

Pack Size Price Stock Quantity
1ml RMB692.00 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Boiling point: 515.4±60.0 °C(Predicted)
Density  1.20±0.1 g/cm3(Predicted)
storage temp.  -20°C
solubility  Soluble in DMSO (up to 40 mg/ml), or in Ethanol (up to 20 mg/ml)
pka 5.37±0.10(Predicted)
form  solid
color  White
Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

Description and Uses

ML323 (1571424-83-5) is a potent and reversible USP1-UAF1 deubiquitinase complex inhibitor with excellent selectivity against human DUBs, deSUMOylase, deneddylase and unrelated proteases, IC50=76 nM in a ubiquitin-rhodamine 110 assay.1 In H1299 non-small cell lung cancer cells treatment with ML323 dose dependently and robustly increased levels of monoubiquitinated PCNA compared to untreated cells at concentrations as low as 1 μM.1 It potentiates cisplatin cytotoxicity in non-small cell lung cancer and osteosarcoma cells.2? ML323 inhibition of upregulated USP1 in BRCA1-deficient tumor cells results in replication fork destabilization and decreased viability.3

ML323 is a highly potent and selective USP1-UAF1 inhibitor.

Safety

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P280-P305+P351+P338
HS Code  29299090

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