L-Buthionine-sulfoximine , 10mMinWater , 83730-53-4
Synonym(s):
L- Buthionine Sulfoximine - CAS 83730-53-4 - Calbiochem;L-BSO
| Pack Size | Price | Stock | Quantity |
| 1ml | RMB190.40 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 224-228 °C (dec.) |
| Boiling point: | 382.3±52.0 °C(Predicted) |
| Density | 1.29 |
| refractive index | 1.6300 (estimate) |
| storage temp. | -20°C |
| solubility | H2O: 50 mg/mL, clear, colorless to faintly yellow |
| form | Fine Powder |
| color | White |
| BRN | 2367136 |
| Stability: | Stable for 2 years from date of purchase as supplied. Solutions are not stable and must be prepared fresh daily. |
| CAS DataBase Reference | 83730-53-4 |
Description and Uses
L-Buthionine-(S,R)-sulfoximine is an irreversible inhibitor of γ-glutamylcysteine synthetase (Ki <100 μM), the rate-limiting enzyme for L-glutathione (GSH) synthesis, that induces oxidative stress in cells by depleting GSH. Administration of L-buthionine-(S,R)-sulfoximine leads to decreased GSH levels in virtually all tissues and is associated with tissue damage and apoptosis. Whereas elevated glutathione levels are associated with tumor cell resistance, L-buthionine-(S,R)-sulfoximine has been shown to enhance the toxicity of various chemotherapeutic agents in drug-resistant tumors.
L-Buthionine-(S,R)-sulfoximine is a potent and specific inhibitor of alpha-glutamylcysteine synthetase.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 22-24/25 |
| WGK Germany | 3 |
| RTECS | EK7713440 |
| F | 10 |
| HS Code | 29309090 |
