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A7674758

GuanethidineMonosulfate , 10mMinWater , 645-43-2

Synonym(s):
1-(2-Guanidinoethyl)octahydroazocine;Guanethidine monosulfate (1:1)

CAS NO.:645-43-2

Empirical Formula: C10H24N4O4S

Molecular Weight: 296.39

MDL number: MFCD00035403

EINECS: 211-442-0

Pack Size Price Stock Quantity
1ml RMB159.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 276-281 °C
storage temp.  2-8°C
solubility  Freely soluble in water, practically insoluble in ethanol (96 per cent)
form  Solid
color  White to Off-White
Stability: Hygroscopic
InChIKey YUFWAVFNITUSHI-UHFFFAOYSA-N
CAS DataBase Reference 645-43-2(CAS DataBase Reference)

Description and Uses

Guanethidine is an antihypertensive compound that competes with norepinephrine for transport into presynaptic terminals of adrenergic neurons by the norepinephrine transporter. Once guanethidine has entered the nerve, it becomes concentrated in synaptic vesicles, depleting endogenous norepinephrine, and thus, reducing the release of norepinephrine in response to action potentials. Guanethidine’s actions are restricted to peripheral nerve terminals because its basic guanidine group does not allow passage through the blood brain barrier. Its use has been explored in the relief of chronic pain caused by complex regional pain syndrome.

Guanethidine Monosulfate acts as an antihypertensive; antiglaucoma

Safety

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P264-P270-P301+P312+P330-P501
Hazard Codes  Xn
Risk Statements  22
Safety Statements  25-36
RTECS  MF3150000
HS Code  2933999552

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