Home Categories Organic Chemistry PotassiumOxonate
A7663658

PotassiumOxonate , 10mMinWater , 2207-75-2

Synonym(s):
Allantoxanic acid;Anti-Kidney superoxide-producing NADPH oxidase;Anti-KOX-1;Anti-NADPH oxidase 4;Anti-Renal NAD(P)H-oxidase

CAS NO.:2207-75-2

Empirical Formula: C4H2KN3O4

Molecular Weight: 195.17

MDL number: MFCD00010565

EINECS: 218-627-5

Pack Size Price Stock Quantity
1ml RMB159.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 300 °C(lit.)
storage temp.  Inert atmosphere,2-8°C
solubility  Aqueous Base (Slightly), Water (Slightly, Heated, Sonicated)
form  Powder
color  White
Water Solubility  Soluble in hot water.

Description and Uses

Oxonic acid is a uricase inhibitor that prevents metabolism and excretion of uric acid and induces embryotoxicity and nephrotoxicity in rats. It is a component of S-1, a mixture containing a prodrug of the antitumor agent 5-fluorouracil (5-FU; ), that suppresses the gastrointestinal toxicity of 5-FU without inhibiting its antitumor activity in rats. Formulations containing oxonic acid have been used to treat gastric, pancreatic, lung, head, neck, and breast carcinomas.

Oxonic acid potassium salt is an inhibitor of uricase. The product from Sigma has been used for the inhibition of 5-fluorouracil-induced gastrointestinal toxicity without the loss of its antitumor activity in rats. It has also been used to induce hyperuricemia in rats; as it inhibits uric acid metabolism.

Safety

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
Safety Statements  24/25
WGK Germany  3
RTECS  RR4580000
HS Code  29349990

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