Tobramycin , Potency≥900μG/mg,98% , 32986-56-4

Synonym(s):
Nebramycin Factor 6;O-[3-Amino-3-deoxy-α-D-glucopyranosyl-(1→6)]-O-[2,6-diamino-2,3,6-trideoxy-α-D-ribohexopyranosyl-(1→4)]-2-deoxy-D-streptamine;Tobramycin, Free Base - CAS 32986-56-4 - Calbiochem

CAS NO.：32986-56-4

Empirical Formula: C18H37N5O9

Molecular Weight: 467.52

MDL number: MFCD00077885

EINECS: 251-322-5

PRODUCT Properties

• Melting point: 178 °C
• alpha: D20 +129° (c = 1 in water)
• Boiling point: 570.01°C (rough estimate)
• Density: 1.3458 (rough estimate)
• refractive index: 143 ° (C=4, H2O)
• storage temp.: Keep in dark place,Inert atmosphere,2-8°C
• solubility: H₂O: 50 mg/mL, clear, faintly yellow
• pka: pKa 6.7 (Uncertain);8.3 (Uncertain);9.9 (Uncertain)
• form: White to off-white solid
• color: white to off-white
• Water Solubility: Soluble in water
• Merck: 14,9490
• BRN: 1357507
• Stability: Hygroscopic

Description and Uses

Tobramycin is one component (factor 6) of a mixture produced by fermentation of Streptomyces tenebrari us. Lacking the C-3′ hydroxyl group, it is not a substrate for APH(3′)-1 and APH(3′)-II and so has an intrinsically broader spectrum than kanamycin. It is a substrate, however, for adenylation at C-2′ by ANT (2′) and acetylation at C-3 by AAC(3)-I and AAC(3)-II and at C-2′ by AAC(2′).

Antihypertensive

Safety

• Symbol(GHS): GHS08
• Signal word: Warning
• Hazard statements: H361f
• Precautionary statements: P201-P202-P280-P308+P313-P405-P501
• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 26-37/39
• WGK Germany: 2
• RTECS: WK2100000
• F: 3-10
• HS Code: 29419090
• Toxicity: LD50 in mice, rats (mg/kg): 441, 969 s.c. (Welles)