Home Categories Biochemical Engineering LDK378
A7633858

LDK378 , 10mMinDMSO , 1032900-25-6

CAS NO.:1032900-25-6

Empirical Formula: C28H36ClN5O3S

Molecular Weight: 558.14

MDL number: MFCD26142648

EINECS: 811-457-8

Pack Size Price Stock Quantity
1ml RMB159.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 173-175°C
Boiling point: 720.7±70.0 °C(Predicted)
Density  1.251±0.06 g/cm3(Predicted)
storage temp.  -20°C Freezer
solubility  Chloroform (Slightly), Methanol (Slightly)
pka 10.16±0.10(Predicted)
form  Off-white solid.
color  White to Off-White

Description and Uses

Ceritinib (previously LDK378l, brand name Zykadia; Novartis Pharmaceuticals) is an oral small molecule tyrosine kinase inhibitor of ALK [87]. Preclinical studies suggested that it would inhibit ROS1 as well [88, 89].

5-Chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine, is a Anaplastic lymphoma kinase (ALK) inhibitor.

Safety

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H320-H335
Precautionary statements  P261-P280-P301+P312-P302+P352-P305+P351+P338

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