E-64c , 10mMinDMSO , 76684-89-4
Synonym(s):
(2S,3S)-trans-Epoxysuccinyl-L -leucylamido-3-methylbutane
| Pack Size | Price | Stock | Quantity |
| 1ml | RMB400.00 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| solubility | ≥31.4 mg/mL in DMSO; insoluble in H2O; ≥111.8 mg/mL in EtOH |
| form | White to off-white solid |
| color | White to off-white |
| InChIKey | SCMSYZJDIQPSDI-SRVKXCTJSA-N |
Description and Uses
E-64c is an active metabolite of the protease inhibitor E-64d . E-64c inhibits the cysteine proteases cathepsin B, cathepsin H, and papain but not the serine proteases trypsin, chymotrypsin, or elastase. It reduces the autocatalytic activity of the foot-and-mouth-disease virus (FMDV) leader protease when used at concentrations ranging from 0.1 to 1 mg/ml. E-64c reduces infection of HEK293T cells by an HIV-based virus system pseudotyped with severe acute respiratory syndrome coronavirus (SARS-CoV) surface glycoprotein, also known as the spike glycoprotein, in a concentration-dependent manner.
E-64c is a cysteine protease inhibitor used for detecting autophagy in plants.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| WGK Germany | 3 |
| RTECS | RR0404200 |
| HS Code | 29241990 |
