Home Categories API Neomycinsulfate
A7602658

Neomycinsulfate , 10mMinWater , 1405-10-3

Synonym(s):
Neomycin sulfate;Neomycin Sulfate - CAS 1405-10-3 - Calbiochem;Neomycin Sulfate, γ-Irradiated, Tissue Culture Grade - CAS 1405-10-3 - Calbiochem;Neomycin sulphate;Neomycin trisulfate salt

CAS NO.:1405-10-3

Empirical Formula: C23H48N6O17S

Molecular Weight: 712.72

MDL number: MFCD00037007

EINECS: 215-773-1

Pack Size Price Stock Quantity
1ml RMB399.20 In Stock
others     Enquire
Update time: 2022-07-08

PRODUCT Properties

Melting point: >187°C (dec.)
alpha  D20 +54° (c = 2 in H2O)
refractive index  56 ° (C=10, H2O)
Flash point: 56℃
storage temp.  2-8°C
solubility  H2O: 50 mg/mL As a stock solution. Stock solutions should be filter sterilized and stored at 2-8°C. Stable at 37°C for 5 days.
form  powder
color  white to slightly yellow
PH 5.0-7.5 (50g/l, H2O, 20℃)
Water Solubility  Soluble in water
Merck  14,6454
Stability: Stable. Incompatible with strong oxidizing agents.
InChIKey OIXVKQDWLFHVGR-VTSVPHRWSA-N
LogP -3.655 (est)

Description and Uses

Neomycin sulfate is an aminoglycoside antibiotic and calcium channel protein inhibitor. Neomycin sulfate also binds to prokaryotic ribosomes inhibiting translation and is effective against gram-positive and gram-negative bacteria. Neomycin sulfate inhibits PLC (Phospholipase C) via binding to inositol phospholipids. It also inhibits phosphatidylcholine-PLD activity and induces Ca2+ mobilization and PLA2 activation in human platelets. Neomycin sulfate inhibits DNase I induced DNA degradation. It is used to prevent or treat skin infections caused by bacteria. It is not effective against fungal or viral infections.

Neomycin sulfate is an aminoglycoside antibiotic produced by S. fradiae that inhibits protein translation by binding to the small subunit of prokaryotic ribosomes. It blocks voltage-sensitive Ca2+ channels and is a potent inhibitor of skeletal muscle sarcoplasmic reticulum Ca2+ release. NEOMYCIN SULFATE has been shown to inhibit inositol phospholipid turnover, phospholipase C, and phosphatidylcholine-phospholipase D activity (IC50 = 65 μM). It is highly effective against Gram-positive and Gram-negative bacteria and is commonly used for the prevention of bacterial contamination of cell cultures.

Safety

Symbol(GHS) 
GHS08
Signal word  Danger
Hazard statements  H317-H334
Precautionary statements  P261-P280-P342+P311
Hazard Codes  Xn,Xi
Risk Statements  42/43-22
Safety Statements  23-36/37-45-22-36-24/25
WGK Germany  3
RTECS  QP4375000
8
TSCA  Yes
HS Code  29419000
Toxicity LD50 oral in mouse: > 8gm

RELATED PRODUCTS