[10]-Gingerol , 10mMinDMSO , 23513-15-7

Synonym(s):
(S)- 5-Hydroxy-1-(4-hydroxy-3-methoxyphenyl)-3-tetradecanone;10-Gingerol

CAS NO.：23513-15-7

Empirical Formula: C21H34O4

Molecular Weight: 350.49

MDL number: MFCD01682694

PRODUCT Properties

• Melting point: 56-58 °C
• Boiling point: 499.7±35.0 °C(Predicted)
• Density: 1.037±0.06 g/cm3(Predicted)
• Flash point: 166℃
• storage temp.: 2-8°C
• solubility: methanol: soluble5mg/mL, clear, colorless
• form: Solid
• pka: 10.02±0.20(Predicted)
• color: Yellow
• Water Solubility: practically insoluble in water
• InChIKey: AIULWNKTYPZYAN-SFHVURJKSA-N
• LogP: 4.900 (est)

Description and Uses

10-Gingerol is a phenol that has been found in Z. officinale and has diverse biological activities. It scavenges DPPH , superoxide, and hydroxyl radicals in cell-free assays (IC₅₀s = 10.47, 1.68, and 1.35 μM, respectively) and inhibits oxidative burst induced by N-formyl-Met-Leu-Phe (fMLP; ) in isolated human polymorphonuclear (PMN) neutrophils when used at a concentration of 6 μM. 10-Gingerol inhibits NETosis and the production of reactive oxygen species (ROS) induced by LPS or lupus-relevant stimuli, including ribonucleoprotein-containing immune complexes and anti-phospholipid antibodies, in isolated human neutrophils. It is active against M. avium and M. tuberculosis (MICs = 25 and 50 μg/ml, respectively). 10-Gingerol (200 μM) is also cytotoxic to human MDA-MB-231 and MDA-MB-468 and murine 4T1 and EO771 mammary carcinoma cells.

(+)-(S)-[10]-Gingerol has been observed to exhibit anti-oxidant behaviour towards lipids and is effective in suppressing obesity and adipose tissue inflammation.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319-H335
• Precautionary statements: P261-P264-P271-P280-P302+P352-P305+P351+P338
• Risk Statements: 53
• Safety Statements: 24/25
• WGK Germany: 3
• HS Code: 29145019