Home Categories Organic Chemistry Sodium methanethiolate
A7474812

Sodium methanethiolate , 95% , 5188-07-8

Synonym(s):
Methanethiol sodium salt;Sodium methanethiolate;Sodium methanethiolate solution;Sodium thiomethoxide;Sodium thiomethoxide solution

CAS NO.:5188-07-8

Empirical Formula: CH3NaS

Molecular Weight: 70.09

MDL number: MFCD00174316

EINECS: 225-969-9

Pack Size Price Stock Quantity
1g RMB263.20 In Stock
5G RMB748.80 In Stock
25G RMB3103.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Density  1.12[at 20℃]
vapor pressure  29hPa at 25℃
Flash point: 27°C
storage temp.  Air and moisture sensitive. Store under inert gas. Sensitive to carbon dioxide Exposure to moisture.
solubility  soluble in Water
form  Powder
color  White to off-white
Water Solubility  soluble
Merck  14,5956
BRN  3592983
InChI InChI=1S/CH4S.Na/c1-2;/h2H,1H3;/q;+1/p-1
InChIKey RMBAVIFYHOYIFM-UHFFFAOYSA-M
SMILES CS[Na]
LogP -2.33 at 20℃
CAS DataBase Reference 5188-07-8(CAS DataBase Reference)
EPA Substance Registry System Methanethiol, sodium salt (5188-07-8)

Description and Uses

Sodium methanethiolate or sodium thiomethoxide (CH3SNa, MeSNa) is the sodium conjugate base of methanethiol. This compound is commercially available as a white solid. Sodium Methanethiolate is used as a nucleophile in organic synthesis. This compound is also being used as a reagent to synthesize thiol-based suberoylanilide hydroxamic acid (SAHA) analogues, compounds that act as potent histone deacetylase inhibitors. It reacts with trifluoroacetic acid and water to produce the active form of sodium trifluoroacetate. The reaction mechanism is likely due to the formation of a bicyclic heterocycle that has been shown to be effective against a number of bacteria.

Used to prepare a C-21 thioether of methyl 16-prednisolonecarboxylate by mesylate displacement.

Safety

Symbol(GHS) 
GHS02,GHS05,GHS07
Signal word  Danger
Hazard statements  H226-H302-H314
Precautionary statements  P210-P280-P301+P312+P330-P301+P330+P331-P303+P361+P353-P305+P351+P338+P310
Hazard Codes  C,F
Risk Statements  31-34-20/21/22-11-35-25-10
Safety Statements  26-36/37/39-45-16
RIDADR  UN 3263 8/PG 3
WGK Germany  3
1-34-10-13
HazardClass  4.3
PackingGroup  II
HS Code  29309090

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