Sodium methanethiolate , 95% , 5188-07-8

Synonym(s):
Methanethiol sodium salt;Sodium methanethiolate;Sodium methanethiolate solution;Sodium thiomethoxide;Sodium thiomethoxide solution

CAS NO.：5188-07-8

Empirical Formula: CH3NaS

Molecular Weight: 70.09

MDL number: MFCD00174316

EINECS: 225-969-9

PRODUCT Properties

• Density: 1.12[at 20℃]
• vapor pressure: 29hPa at 25℃
• Flash point: 27°C
• storage temp.: Air and moisture sensitive. Store under inert gas. Sensitive to carbon dioxide Exposure to moisture.
• solubility: soluble in Water
• form: Powder
• color: White to off-white
• Water Solubility: soluble
• Merck: 14,5956
• BRN: 3592983
• InChI: InChI=1S/CH4S.Na/c1-2;/h2H,1H3;/q;+1/p-1
• InChIKey: RMBAVIFYHOYIFM-UHFFFAOYSA-M
• SMILES: CS[Na]
• LogP: -2.33 at 20℃

Description and Uses

Sodium methanethiolate or sodium thiomethoxide (CH3SNa, MeSNa) is the sodium conjugate base of methanethiol. This compound is commercially available as a white solid. Sodium Methanethiolate is used as a nucleophile in organic synthesis. This compound is also being used as a reagent to synthesize thiol-based suberoylanilide hydroxamic acid (SAHA) analogues, compounds that act as potent histone deacetylase inhibitors. It reacts with trifluoroacetic acid and water to produce the active form of sodium trifluoroacetate. The reaction mechanism is likely due to the formation of a bicyclic heterocycle that has been shown to be effective against a number of bacteria.

Used to prepare a C-21 thioether of methyl 16-prednisolonecarboxylate by mesylate displacement.

Safety

• Symbol(GHS): GHS02,GHS05,GHS07
• Signal word: Danger
• Hazard statements: H226-H302-H314
• Precautionary statements: P210-P280-P301+P312+P330-P301+P330+P331-P303+P361+P353-P305+P351+P338+P310
• Hazard Codes: C,F
• Risk Statements: 31-34-20/21/22-11-35-25-10
• Safety Statements: 26-36/37/39-45-16
• RIDADR: UN 3263 8/PG 3
• WGK Germany: 3
• F: 1-34-10-13
• HazardClass: 4.3
• PackingGroup: II
• HS Code: 29309090