A7378312
SB216763 , ≥98% , 280744-09-4
Synonym(s):
3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione;GSK-3 Inhibitor IV, SB-216763 - CAS 280744-09-4 - Calbiochem;SB-216763
CAS NO.：280744-09-4
Empirical Formula: C19H12Cl2N2O2
Molecular Weight: 371.22
MDL number: MFCD09753369
| Pack Size | Price | Stock | Quantity |
| 5MG | RMB119.20 | In Stock |
|
| 10MG | RMB207.20 | In Stock |
|
| 25mg | RMB399.20 | In Stock |
|
| 50MG | RMB719.20 | In Stock |
|
| 100mg | RMB1295.20 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | 287-288.6 °C(lit.) |
| Boiling point: | 598.1±50.0 °C(Predicted) |
| Density | 1.47±0.1 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | DMSO: 20 mg/mL, soluble |
| form | Orange solid |
| pka | 7.27±0.60(Predicted) |
| color | orange |
| Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
Description and Uses
SB-216763 (280744-09-4) is a potent and selective inhibitor of glycogen synthase kinase-1 (GSK-3) IC50=34.3 nM.1 Acts at the ATP-binding domain. Displays protective effects in lung fibrosis mouse model.2 Displays neuroprotective effects on cultured neurons.3 SB-216763 maintains mouse embryonic stem cells in a pluripotent state.4?Cell permeable.
SB 216763 is a potent and selective cell permeale ATP-competitive inhibitor of GSK3a. It stimulates glycogen synthesis in Chang human liver cells.
